ID A0A182QYF5_9DIPT Unreviewed; 977 AA.
AC A0A182QYF5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
OS Anopheles farauti.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=69004 {ECO:0000313|EnsemblMetazoa:AFAF019396-PA, ECO:0000313|Proteomes:UP000075886};
RN [1] {ECO:0000313|Proteomes:UP000075886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FAR1 {ECO:0000313|Proteomes:UP000075886};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles farauti FAR1 (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AFAF019396-PA}
RP IDENTIFICATION.
RC STRAIN=FAR1 {ECO:0000313|EnsemblMetazoa:AFAF019396-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AXCN02001398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182QYF5; -.
DR STRING; 69004.A0A182QYF5; -.
DR EnsemblMetazoa; AFAF019396-RA; AFAF019396-PA; AFAF019396.
DR VEuPathDB; VectorBase:AFAF019396; -.
DR OrthoDB; 5476210at2759; -.
DR Proteomes; UP000075886; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:UniProt.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR PANTHER; PTHR47143; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS; 1.
DR PANTHER; PTHR47143:SF3; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 9.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 6.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 535..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 768..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 169..201
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 270..303
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 307..339
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 340..364
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 374..408
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 409..441
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 545..797
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 928..969
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 977 AA; 109063 MW; 3CED49BCF7FC6622 CRC64;
MENFGYKEGS SKPKRRLTAK SMKRRNSQIP IKPRFSISPE LSVHWMNDQE AMVTEDFEYM
KIGPSPPAES APIIFDSYEE SSPEFGVELS SESIRTSLID QLRLASGRVH LLDSIEQGNM
VAANVAEFFG GASKTEKNIC FLWAAFAKRW DLLDALMEHG AELAFHDTSG FTALHLSAFS
DCLNCASVLV AKGIDVNLQP KAYTPLQCAA FGNAAHTALF LLGKGARLEL CTRRPGGEET
LLHCAVRANA LACVRLFIAE GMDVNSIKPS GMNAIHLAAD LGHVECLRVL LGAPGADANI
RIGIREKEST ALHLAADEGN AACVALLLEQ GAEAGLKNHR GFTPLHLASR TSSLDCVDLL
LRAGTADPNE EDFDMRTPLH TAIGRSESAF HIIETLICWG ADVNKKDVFG FTPLHLAALD
GLAHCVEILL FYDADVTAKT KKGTTALNVI TRKTPGSLAM ITQKMDDAMT LIHSQNPSEK
EVELELDFRT ILQHCYPREI SYLNTLVDEG QKEMLQHPLC SAFIYIKWGK IRKYYIARLL
FCFIFILFLT LYVLTALAHN CYNGSKDMEE TIQEQELCQK QSILGNMLRR NPFVMEMQWL
VLVAITFVEI CRKLYGITGY SSIRRYVTQM ENITEWFIIV SVFVISYIYT KRTYTWQNHI
GAFAVLLGWT HLMVMIGQLP VFGAYVAMYT KVQVEFAKLF IAYSCMLVGF TISFCVIFPS
SSSFENPFMG FITVLVMMVG ELDLELLIND PDGKDPPFML ELSAQITFVL FLLFVTVILM
NLLVGIAVDD IQALKKTATL SKLVGQTKLI SYIESALFNG WLPNWLRSLL HYTALVSPRA
YRVILSVKPL NPEEKRLPRN IMMAAYEIAK EKEQQLAAVV LPGEQPPQDT QHQHQHQHQQ
HQPQQQEQQH PTGPPTEGGV VTRPDGDIQA LASKIDQSAE KMNDVTRELQ ELRAVLQQNQ
QLIDEIARQV CGGGVKE
//
