ID   A0A182R2G6_ANOFN        Unreviewed;       556 AA.
AC   A0A182R2G6;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 2.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Pickpocket {ECO:0008006|Google:ProtNLM};
OS   Anopheles funestus (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN000356-PA, ECO:0000313|Proteomes:UP000075900};
RN   [1] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA   Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA   Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA   Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT   "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT   Middle East: occurrence data, distribution maps and bionomic precis.";
RL   Parasit. Vectors 3:117-117(2010).
RN   [2] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA   Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA   Besansky N.J.;
RT   "A chromosome-scale assembly of the major African malaria vector Anopheles
RT   funestus.";
RL   Gigascience 8:0-0(2019).
RN   [3] {ECO:0000313|EnsemblMetazoa:AFUN000356-PA}
RP   IDENTIFICATION.
RC   STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN000356-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
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DR   AlphaFoldDB; A0A182R2G6; -.
DR   STRING; 62324.A0A182R2G6; -.
DR   EnsemblMetazoa; AFUN000356-RA; AFUN000356-PA; AFUN000356.
DR   VEuPathDB; VectorBase:AFUN000356; -.
DR   VEuPathDB; VectorBase:AFUN2_007835; -.
DR   OrthoDB; 3414706at2759; -.
DR   Proteomes; UP000075900; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF237; PICKPOCKET 16-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        50..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        446..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   556 AA;  63345 MW;  505C47F9D9704A70 CRC64;
     MNLKQVYRTV CETFRSAVQS FCENTTLHGL RYVYGGDRTD ASRNGGMLRM IWLLACMVCI
     GFTMIMGMIA WMRFRTTPTI TTIETMTYPI WNIPFPAVTV CNINKIDTRK AAPIIDRLVQ
     EYGLSEANAT GLLIAQASLV NFEAVNSTYL ELEMFLGRLG WNPNKLLLEL SQPCEELIKV
     CYWLGSEIPC PKVIHRTRTD NGFCCSYNVD SMMQSVPVPE NQTHPRTPYH PKRLSGAGRH
     VGLSILIDVQ PDTYMAPTKS YYGAEVYIHD SSDFPSDADF EHVAQPGWDV VMSVIPLPIE
     SSNTMSQVPE NMRKCFLPEE SNAQSRENFN LNVCMAECRL RTILKLCNCI PFYYSDLRYF
     YSLRTDDSLD SELQDVEFGM DCDCKPPCSV LNYNVQTIVS QRKSHRFTSA NFGGRNVSMY
     ATLNVHFKDI YCVKYKRDAY MTWDSLVATF GGIFGLCMGG SVLSIVELIY YFTIKPFTIY
     QTGKKRKRIT PNRKVIVRPY VSRYDGISQY PVGYFSRRNV LARERSAGKK LTKPCVPVKK
     ATLGHDPQTD VISFIY
//