ID   A0A182R2H4_ANOFN        Unreviewed;       509 AA.
AC   A0A182R2H4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 2.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Sodium channel protein Nach {ECO:0008006|Google:ProtNLM};
OS   Anopheles funestus (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN000365-PA, ECO:0000313|Proteomes:UP000075900};
RN   [1] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA   Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA   Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA   Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT   "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT   Middle East: occurrence data, distribution maps and bionomic precis.";
RL   Parasit. Vectors 3:117-117(2010).
RN   [2] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA   Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA   Besansky N.J.;
RT   "A chromosome-scale assembly of the major African malaria vector Anopheles
RT   funestus.";
RL   Gigascience 8:0-0(2019).
RN   [3] {ECO:0000313|EnsemblMetazoa:AFUN000365-PA}
RP   IDENTIFICATION.
RC   STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN000365-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
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DR   AlphaFoldDB; A0A182R2H4; -.
DR   STRING; 62324.A0A182R2H4; -.
DR   EnsemblMetazoa; AFUN000365-RA; AFUN000365-PA; AFUN000365.
DR   VEuPathDB; VectorBase:AFUN000365; -.
DR   VEuPathDB; VectorBase:AFUN2_011831; -.
DR   OrthoDB; 3199642at2759; -.
DR   Proteomes; UP000075900; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF285; PICKPOCKET 3; 1.
DR   Pfam; PF00858; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        61..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   509 AA;  58345 MW;  537F6A5870A93454 CRC64;
     MTLCEGEYTI STTVTNHKMV KKVEKASSTK EASFNQKLFA VLNVPGLQYV FDHRKHPLER
     IFWVLVILAA LRGMLFLGQY QYARYRANPT AIQMDKNYRD WIGIMPGLTF CFHDRIDWKR
     AEEYLERFHF SIGLTGYETT REGLSSNETT GTTRYLADFV QTLVGATATD LGNLSRFLND
     SRLAIDVNVL ELISMVHPNH DIAINSFEPA HGTLLQVHQI VTERGICYAL NAPLALLLHV
     NGTGQWASEK DVPGWSPISC EFSKHQCYMK LDMYRSTVSY AIHSPYEVAT SDQLFTHVEE
     SDELVAVYSV LETVANERLK DLTVRQRNCY FYDEVYEQLP LYSHNLCIMS CRARRALAAC
     RCRPHFYPFA EGPPCNVQGL HCLQQHPDWY NDGDCKCLKS CTDVGYYVAS LSKTQWTAEG
     GIPFTHKASL RWEILQPKTR LRRVLIFSYE DLLVSFGGAV ALFLGKNGFY LSKIVEFLVL
     ETFGWVRRKF CMRNDRKKNR TKPAVTVSK
//