ID   A0A182R2M3_ANOFN        Unreviewed;       922 AA.
AC   A0A182R2M3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 2.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=PHD-type domain-containing protein {ECO:0000259|PROSITE:PS50016};
OS   Anopheles funestus (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN000414-PA, ECO:0000313|Proteomes:UP000075900};
RN   [1] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA   Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA   Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA   Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT   "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT   Middle East: occurrence data, distribution maps and bionomic precis.";
RL   Parasit. Vectors 3:117-117(2010).
RN   [2] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA   Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA   Besansky N.J.;
RT   "A chromosome-scale assembly of the major African malaria vector Anopheles
RT   funestus.";
RL   Gigascience 8:0-0(2019).
RN   [3] {ECO:0000313|EnsemblMetazoa:AFUN000414-PA}
RP   IDENTIFICATION.
RC   STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN000414-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NFX1 family.
CC       {ECO:0000256|ARBA:ARBA00007269}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A182R2M3; -.
DR   STRING; 62324.A0A182R2M3; -.
DR   EnsemblMetazoa; AFUN000414-RA; AFUN000414-PA; AFUN000414.
DR   VEuPathDB; VectorBase:AFUN000414; -.
DR   VEuPathDB; VectorBase:AFUN2_001100; -.
DR   OrthoDB; 1412at2759; -.
DR   Proteomes; UP000075900; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd06008; NF-X1-zinc-finger; 4.
DR   InterPro; IPR034078; NFX1_fam.
DR   InterPro; IPR000967; Znf_NFX1.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   PANTHER; PTHR12360:SF1; NF-X1-TYPE ZINC FINGER PROTEIN NFXL1; 1.
DR   PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR   Pfam; PF01422; zf-NF-X1; 10.
DR   SMART; SM00438; ZnF_NFX; 10.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00146}.
FT   TRANSMEM        900..920
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          148..225
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          841..868
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        32..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   922 AA;  103105 MW;  45BB2335457CAF66 CRC64;
     MAYRNRSKIV PKEPNAWNVP VQPKPDHVGG KTRKTSTGST SKLAPPSGTP EQNVSGSKIP
     LPTASSSMLK KSQDKFNQVQ RQHAEKAKKY AVEYVSSDDD EEQDETNGED GDVATRNILG
     DVLKNYHGID ADVGKTQEYL QNLLESRNAV CLICIETVKR ADRIWSCSAC YTFFHLMCIQ
     RWANDSMSMK RITHEQQEGY YNNRGEYIPK PALNVQWDCP KCRREYLPEE IPRHYECFCG
     KERDPSAHPW MIPHSCGEPC EKKLAPACGH TCRLLCHPGP CPPCPQTINV SCRCGCSPVK
     TIRCAQKSWI CTKKCKRTLS CGIHECGTQC HDPGSCPPCQ NRSDQPCLCG ALTKEVNCHE
     SRWQCGTVCN RPLSCGLHHC DRVCHADPCG DCPLGLPRSC PCGKSETRAA SCAERIGTCG
     DTCEKLLVCE QHRCPERCHQ GPCGNCLELV PKVCRCGSTK KPIACHREAI CEGRCKRMRN
     CGKHQCNRKC CDGQCQLCDR VCGKTLPCGK HKCSSLCHQG PCYPCNQKSS VKCRCGGTTV
     EVACGRERKA NAPKCNLPCR VASKCHHPNT HSCHTGECPA CTQPCGERND TTNCEHPCRA
     KCHDAVRVVT RDKNFKPVGP WDVPKEIVEV KTLPHPACTE KIPVMCLGGH ETVDWPCSNS
     KPSSCGRPCD RLLKCGVHRC PLPCHKVTHR ASTTQDSRCE ACSAGCTLTR PAGCTHSCTL
     PCHKPPCNPC LVSIKAHCYC GITQVFYKCH EFYPSGMEDK GSQELAELDR RRESFLSCGQ
     KCIKNFPCGH RCFSICHPGR CPNPELCSKK VKISCKCTHR KAEVSCKMAR SNPTLDCDQQ
     CEAIRAQKQE EQDRKEREAR AQQELENQRE LDEYERKFNK RKYRERKRHQ VQQEETGRHW
     AVYVLPVVAV LIGVAAYILF TE
//