ID   A0A182R390_ANOFN        Unreviewed;      1187 AA.
AC   A0A182R390;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 2.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=C2 domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles funestus (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN000631-PA, ECO:0000313|Proteomes:UP000075900};
RN   [1] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA   Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA   Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA   Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT   "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT   Middle East: occurrence data, distribution maps and bionomic precis.";
RL   Parasit. Vectors 3:117-117(2010).
RN   [2] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA   Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA   Besansky N.J.;
RT   "A chromosome-scale assembly of the major African malaria vector Anopheles
RT   funestus.";
RL   Gigascience 8:0-0(2019).
RN   [3] {ECO:0000313|EnsemblMetazoa:AFUN000631-PA}
RP   IDENTIFICATION.
RC   STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN000631-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the unc-13 family.
CC       {ECO:0000256|ARBA:ARBA00005823}.
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DR   AlphaFoldDB; A0A182R390; -.
DR   EnsemblMetazoa; AFUN000631-RA; AFUN000631-PA; AFUN000631.
DR   VEuPathDB; VectorBase:AFUN000631; -.
DR   VEuPathDB; VectorBase:AFUN2_003403; -.
DR   OrthoDB; 3435193at2759; -.
DR   Proteomes; UP000075900; Unassembled WGS sequence.
DR   CDD; cd00030; C2; 1.
DR   Gene3D; 1.10.357.50; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR014770; Munc13_1.
DR   PANTHER; PTHR45999:SF2; PROTEIN UNC-13 HOMOLOG 4B; 1.
DR   PANTHER; PTHR45999; UNC-13-4A, ISOFORM B; 1.
DR   Pfam; PF00168; C2; 2.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS51258; MHD1; 1.
PE   3: Inferred from homology;
FT   DOMAIN          152..277
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          618..742
FT                   /note="MHD1"
FT                   /evidence="ECO:0000259|PROSITE:PS51258"
FT   DOMAIN          1001..1132
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          57..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1187 AA;  133626 MW;  251FF35638E069F7 CRC64;
     MVEMSVPNDG DRPVKESPGA AASVAVASDG RQGRRKPFFE KFGTLLKQRS DAFLLHVNNP
     VPPHGEESDA PGSHANGGLA GPSTVLGPAG IQPIVANGDV SPAKATDAEN YVEILYEKVL
     HEIKQGNIID RQKKLTQKSL YAYIQEAFGV DETRHAVLEQ RVDTMLAQDI YLRVEIMEAK
     LNPPPDAPEQ LLPNAFVIVY LQEKPRETHR TATIPSTLNP TWNQQFPVAV KQDTKETLII
     EVFNNSNNPN KFLRALRIAR KYLLSLFNPV ASHAKMIGRA SIPLESITST GLISWYNLAK
     KKKPDPQGTL KVKFFFTSKL EKATAKHEYE QMLRCILEYE LRSSSVARYW WAGKLTSEGE
     AILQQYTKCA NLNATEQTLI AWFVYTQVHL TYPLSISLLE SVLDKLCVGY DVALTSDEER
     ERFWDGMRRI LPSCLSIIVK MRKRLAGDKD IVKTVTAVLQ LVSKADQLAA RKGANLFSDA
     TVRALKQIAL DCTKHSTMKE AIVLAVQLGA RTWFEMALSS AIEGSQSNED KLRSLIKFVQ
     LLQSDLLRAK TYYDGVFKSV MDIDYSREIC IQHEARIVSH LRPIVQTICN GFKKITLRME
     QLERRAEMES LDMSSTLFEL YLILKLFLQQ TDTVVQSAHN PYIVEFHQWF RGGIVYYLDV
     FAIKTISRVV TVLEEDDLRK VEPLSNGRLK CSSSTREILE IISQIKIFWD QLAWPDKDEM
     KKFLKRSIGD ICSCCIFYAD RLLSKVKTLE GSSTNATGGI NSAQLATLER SLVVLSNVSI
     LIESLVRLPQ ELGYSQPSAA SGAVTDASEK PRKTSLEQLM ADEMLPIDGL ASWRQKCVRY
     IADHVTQTTR GFIIACSEVT MNGGSPNGNT GTTLAGGFFS SKQHPSPVEN VERLRHWIVQ
     SSTLLTEGLT EADLHTVEQD LWTTLETTMD EIIKKLLEKK DSLATFQRLR TCYEQLIQHY
     FSTLSETIAC STIGERLETF SCTTNELIHR YYLERVRQQD QLEEPENGQV TVRCWFQPDG
     LQIKVLRAEQ LRLPKDYKHS CDSYVKINVL PPDQFGAPLP ELKTKTKSKN FSPIYNETFA
     LKINPVQHSL KDALLMLNVK VSELLGLSQK HIGECFLRLD AIPVVRDASE AHEIAPITIP
     LSLPFTIASY SVTALENRNH DKMAAQFLKK LKQKMGIAPY TMSTLSL
//