ID A0A182R424_ANOFN Unreviewed; 698 AA.
AC A0A182R424;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Cytohesin {ECO:0008006|Google:ProtNLM};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN000915-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN000915-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN000915-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A182R424; -.
DR STRING; 62324.A0A182R424; -.
DR EnsemblMetazoa; AFUN000915-RA; AFUN000915-PA; AFUN000915.
DR EnsemblMetazoa; AFUN000915-RB; AFUN000915-PB; AFUN000915.
DR VEuPathDB; VectorBase:AFUN000915; -.
DR VEuPathDB; VectorBase:AFUN2_011681; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF406; MIP16918P; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
FT DOMAIN 359..546
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 564..679
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 78701 MW; 92DA6125C4D15403 CRC64;
MFSSMPPSAT GGSGTDVKKG PTNWFWSLRR QPKPKKTILE PDKPLQKSCV DLPSATTNGG
TTLFGSNRLD EVVSTSSSSI ERPTAGCTCE YVQVFEPPET TGSISTTATI TTTVSRHQND
ALLESASSDS NLALSSLTSP IEGAATGVQP FATNSLRRRK EQVVYGAKTV TTVTKTTVLN
RQRTYRVGLI FSDNGELLNS NLDLRQLVEE SKRNFLNALG NAGGVENSPV IPPPPRLPSD
PTEEPNNNDQ QRSKESDELQ QFSILNDSNF DFIDDSADLF NRNYPHQPPA SSTVAEPRPA
LLASPAATLP ITKVLRMCNN CKNKSNLVYQ RSCSQPNRKQ INDELNEVES EMKSHESKEE
NKHSNKDKQM ALGRKKFNMD PKKGIEFLYE NQLLRTDPQD VAQFLYKGEG LNKTAIGDYL
GEKNDFNEQV LKAFVELHDF TNLILVQALR QFLWSFRLPG EAQKIDRMME CFAQRYCQLN
PDIFTNTDTC YVLSFAIIML NTSLHNPSVK EKPTVEQFIS MNRGINNGGD LPRELLESLY
ESIRAEPFKI PQDDGNDLMH TFFNPDKEGW LWKQGGRYKS WKRRWFILND NCLYYFEYTT
DKEPRGIIPL ENIAVREVTD RSKPHCFELH ASGGADIIKA CKTDSEGKVV EGKHTVYRMS
AATEEEQQEW INRLNQSISH NPFHDILVQR KKKALAKS
//
