ID A0A182R5A9_ANOFN Unreviewed; 1327 AA.
AC A0A182R5A9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=TOLL-like receptor 7 {ECO:0000313|EnsemblMetazoa:AFUN001351-PA};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN001351-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN001351-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN001351-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR STRING; 62324.A0A182R5A9; -.
DR EnsemblMetazoa; AFUN001351-RA; AFUN001351-PA; AFUN001351.
DR VEuPathDB; VectorBase:AFUN001351; -.
DR VEuPathDB; VectorBase:AFUN2_011702; -.
DR OrthoDB; 927694at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF385; TOLL-LIKE RECEPTOR 7; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 21.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 7.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..1327
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008133905"
FT TRANSMEM 991..1014
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1040..1178
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1239..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1327 AA; 148383 MW; CC0E9941741464CA CRC64;
MYTPIDKMHQ RRMREFNTMV LLLRLAVFVC TLALATCSQC TWEYEKSSVI CRLRTLERTG
LDLQGAEGTS RLDIECSELI LFESQLPRNS FSRLAALGEL RVESCKLLQL PEGAFEGLLA
LKKLSVNTRN YEWGPGKVLE LQAGSMRGLK ELQSLDLSDN NIRALPDGFL CPLTGLKVLN
LTNNRFRSAE ALGLAEKTCA GGSELQALNL AYNELRAVPT GWGVSKLRRL QHLNLEFNNI
SEVHGDALAG LGSLRTLNLS YNHLETLPAG LFAGSRDLRE IHLQGNQIYE LPRGLFHRLE
QLLVLDLSRN QLSSHHVDNG TFSGLIRLVV LNLAHNALTR IDARTFAELY FLQILDLRNN
SIGYIEDNAF LPVYNLHTLN LAENRLHTLD DRLFNGLFVL SKLTLNNNLI SIVEPNVFRN
CSDLKELDLS SNQLTEVPYA IRDLSMLRAL DLGENQIARI ENGTFANLNQ LTGLRLIDNQ
IENVTVGMFS DLPRLSVLNL AKNRVQNIER GSFDRNLDIE AIRLDGNFLT DINGIFATLA
SLLWLNLAEN HLVWFDYAFI PSNLKWLDIH GNYIESLGNY YKLQEEIKVK TLDASHNRLT
DLGPMNVPNS VELLFVNDNH IGTIHANTFI DKVNLARVDL YANALKKLQL HQLRVAPAPT
TDRPLPEFYL GGNPFECDCS MEWMQRVNNL TTRQHPKIMD LPNVECIMPH ARGSPIRPIV
SLQPKDFLCR YETHCFALCH CCDFDACDCE MTCPSNCTCY HDQTWGTNVV DCGNQGAASA
AAGGLRPVPM DATEVYLDGN DIPELQHHVF IGRKNLKVLY ANASHITTIQ NRTFAGLTAL
QTLHLEDNAL QRIHGYEFEN LALLRELYLQ NNALQSIANG SFAPLYSLRV LRLDGNRLVT
MPLFQLQAAQ GNLQALQSLS LGRNPWSCRC RFLPELTAFV ADNAVIVQDP QDVYCADDGV
HRELDFNVSA ACSDFYAGRS VLPGDRLSET YILLMAGAFV LTCLLLLAVL VFVFREPLRF
WLFSRYGVRV FGPRCEDSEK LYDAILLYSA KDAELVARSI AGELENGRPP LRLCLQHRDL
PEDASHLQLL EASRASRRIV VLLSRNFLQT EWSRCELRRA VHDALRGRPH KLVVVEEGGG
VLLEAENDVE LVPYLKTTTV TRVRRGDRHF WEKLRYALPV EAPYRGNNYT IDHHERVKQT
VGASVGSGGG GGGGGGGAVM FRQPPPPAYC PEIDEANYSS ATTATPSPRP SRRGMVEVPT
QRPPSEHIYS SIDSDYSTLE CENMVMAPAG VHRPSWRSAG GHPVQNGGTM HPHGPGAGGH
HVQAYLV
//
