ID A0A182R6C1_ANOFN Unreviewed; 3347 AA.
AC A0A182R6C1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN001717-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN001717-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN001717-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 62324.A0A182R6C1; -.
DR EnsemblMetazoa; AFUN001717-RA; AFUN001717-PA; AFUN001717.
DR VEuPathDB; VectorBase:AFUN001717; -.
DR VEuPathDB; VectorBase:AFUN2_006808; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1922..2073
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2245..2396
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2615..2765
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2957..3123
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2418..2437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 551..578
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3236..3305
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3347 AA; 383961 MW; 3A384F987C073BC0 CRC64;
MGDSLETTLP SMGSEQPPSV EAETVAIIDF DNFSNYLRKA ITVLLPEDDM KSFGPLNAAL
EDSVNQDCIR KFISDPQTQA LYIQRNCFKD DENEPPTEGE EEKDSITYYF GNDVHFTNQR
MASLVCIKRG GLIEADKSIH SQVRLINFSE GSPYETLHAF ISKTLAPYFK SYVKESGRAD
RDGDKMAPSV EKKLAELEMG LLHLQQNIDI PEVTLNINST VAQVVKKCAD EQRKAKITDF
GDKVQDSTFL NTLQNGVNRW IKEIQKVTKL DRDPSSGTAL QEISFWLNLE RALHRIQEKR
ESPEVALTLN ILKHGKRFHA TVSFDTDTGL KQTLAMVADY NPLMKDFPIN DLLSATELDK
IRQAVHSIFN HLRKIRNTKY PIQRCLRLIE AISRDLSQQL LKVLGTRRLM HIPFDEFERV
MNQCFEVFSC WDDEYDKLLG TLREIVKRKR DEHIKMVWRI SPAHKILQQR MEHMRKFRRQ
HEQLRTVIVR VLRPARQPSS ALSGAGDNSV GGEGKQPYSL DTADANAIEE VNLAYENVKE
IECLDISKEG SEAWDAAIKR YEERIDRVEA RITAHLRDQL GTAKNANEMF RIFSRFNALF
VRPHIRGAIR EYQTQLIQRV KDDIEALHEK FKVQYPQSKS CRLSVVRDLP PVAGSIIWAR
QIDNQLTMYL KRVEDVLGRG WESHIDGQKL KADGDSFRAK LSTAEVFQDW ARKVQERNTG
ITGRIFSIEA TRSRTGRGNM FRLRVNFLPE IITLYKEVRN LKSLGFRVPL AIVNKAHQAN
QLYPFAISLI ESIRTYERTL EKLNNRTLAQ NSVFKIEDRA SIIPLVAGLR KEVLSLISEG
IALVWESYKL DPYVQRLSEN VVSFQEKVED LLVVEEQLDV DVRSLETCPY SAATFADILS
KIQHAVDDLS LKQYSNLHVW VARLDEEVEK KLAMRLQAGI QAWTDALTGN KKELDLSMDT
DAPTQPTIRP GGDPQIQRAI HEIRITNQQM YLYPSIEEAR FQIMQQLFAW EAIVTSQTRL
QSSRYQVGLD KPVSQTYRNL LTKLPNKPDP LEGAYAAIEN QIGDVRSYVD EWLRYQSLWD
LQADMLYGRL GEDINLWIKC LNDIKKSRTT FDTSDTRRAY GPIVIDYAKV QAKVTLKYDS
WHKEALSKFG QLLGNEMSTF HTKVSKSRSD LEQQSIEAAS TSDAVCFITY VQSLKKEMLV
WDKQVDVYRE AQRILERQRF QFPNNWLHVD NIEGEWSAFN EIMKRKDSAI QTQVASLQAK
IVAEDKAVET RTVDFLNDWE KNKPTGGRTR PDDALQQLHI FETKFSRLKE ERDNVAKAKE
ALELQESAIP NNSTERMSVV LEELQDLRGV WSELSKVWAQ IDETREKPWL SVQPRKLRQS
LEAMMNQLKE LPARLRMYES YEYVKKLLQS YIKVNMMIVE LKSDALKERH WKQLTKQLRV
SWVLSDLTLG QVWDVNLLKN ESIVKDIILV AQGEMALEEF LKQVRESWQN YELDLINYQN
KCRIIRGWDD LFNKVKEHIN SVAAMKLSPY YKVFEEEALT WEEKLNRINS LFDVWIDVQR
RWVYLEGIFS GSADIKTLLP VETSRFQSIS SEFLGLMKKV AKSPKVMDVL NIPAVQRSLE
RLADLLGKIQ KALGEYLERE RTSFPRFYFV GDEDLLEIIG NSKNVARLQK HFKKMFAGVA
SILLNEDNTV ILGIASREGE EVHFIKPVST VEHPKINEWL SLVEKEMRFT LASYLAQAVQ
DIKQFKDVID TQKYMEWCDK YQAQIVVLAA QILWSEDVEN ALQQTSEGNG GNGKDKTPLH
RVLTTVEATL NVLADSVLQE QPPLRRKKLE HLINEFVHKR TVTRRLIAHG VNNPKSFHWL
CEMRFYFDPR QTEVLQQLTI HMANARFYYG FEYLGVQDRL VQTPLTDRCY LTMTQALEAR
LGGSPFGPAG TGKTESVKAL GNQLGRFVLV FNCDETFDFQ AMGRIFVGLC QVGAWGCFDE
FNRLEERMLS AVSQQIQTIQ EALKSQQDAN RDAQSITVEL VGKQVRVSTD MAIFITMNPG
YAGRSNLPDN LKKLFRSLAM TTPDRQLIAE VMLFSQGFRT AEKLACKIVP FFKLCDEQLS
NQSHYDFGLR ALKSVLVSAG NVKRDRIMKI KDTKKQQGEE NIDEASIAEN LPEQEILIQS
VCETMVPKLV AEDIPLLFSL LSDVFPNVGY TRAEMKGLKD EIRKVCSEEY LVCGEGDEQG
GAWMEKGFGE TWVDKVLQLY QISNLNHGLM MVGPSGSGKS SAWKVLLKAL ERFEGTEGVA
HVIDPKAISK EALYGVLDPN TREWTDGLFT HILRKIIDNV RGEINKRQWI IFDGDVDPEW
VENLNSVLDD NKLLTLPNGE RLSLPPNVRI MFEVQDLKYA TLATVSRCGM VWFSEDVLST
EMIFENYMSR LRHIPLEDGE EESFSGQTKS NEKEDEVTPA LQTQREIAAL LQPYFNSDGL
VVRCLEYAMG QEHIMDFTRL RALSSLFSML NQGARNVLTF NQQHPDFPVP PEQLEQYIPK
LLIYSMLWSF AGDSKLKVRS DLGDFLRSIT TVTLPAQGGN PIIDYEVNIQ GDWVPWSNKV
PVIEIETHKV AAPDVVVPTL DTVRHESLLY TWLAEHKPLV LCGPPGSGKT MTLFSALRAL
PDMEVVGLNF SSATTPELLL KTFDHYCEYR KTPNGVVLAP VQLGKWLVLF CDEINLPDMD
SYGTQRVISF LRQLVEHKGF YRAADQSWVS LERIQFVGAC NPPTDPGRKP LSHRFLRHVP
IIYVDYPGET SLKQIYGTFS RAMLRLMPNL RGYAEPLTNA MVEFYLASQD RFTQDMQPHY
VYSPREMTRW VRGICEAIRP LDNLPVEGLV RLWAHEALRL FQDRLVEESE RRWTNENIDL
VATKHFPSVD REKSLTRPIL YSNWLSKDYM PVNRDELRDY VKARLKVFYE EELDVPLVLF
DEVLEHVLRI DRIFRQPQGH LLLIGVSGAG KTTLSRFVAW MNGLSIFQIK VHNKYTSEDF
DEDLRCVLRR AGCKDEKIAF ILDESNVLDS GFLERMNTLL ANGEVPGLFE GDEYTTLMTQ
CKEGAQREGL MLDSSDELYK WFTQQVMRNL HVVFTMNPST DGLKDRAATS PALFNRCVLN
WFGDWSDSAL FQVGKEFTIR VDLEKPTWSA PDFFPAVCPL VSNTPSHRDA VINSCVYVHQ
TLHKANARLA KRGSRTMAIT PRHYLDFIHH FVKLYSEKRS DLEEQQLHLN VGLNKIAETV
EQVEEMQKSL AVKSQELQAK NEAANAKLKQ MFKDQQEAEI KKVQSQEIQH QLAEQTVKIE
EKRKDVMADL AQVEPAVIDA QAAVGNIKKK QLAEVRLEGN PSDHGEG
//
