ID A0A182R6F4_ANOFN Unreviewed; 666 AA.
AC A0A182R6F4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN001750-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN001750-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN001750-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
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DR AlphaFoldDB; A0A182R6F4; -.
DR STRING; 62324.A0A182R6F4; -.
DR EnsemblMetazoa; AFUN001750-RA; AFUN001750-PA; AFUN001750.
DR VEuPathDB; VectorBase:AFUN001750; -.
DR VEuPathDB; VectorBase:AFUN2_007243; -.
DR OrthoDB; 5474157at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 498..662
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
SQ SEQUENCE 666 AA; 75776 MW; 2B69BB673B18502C CRC64;
MSKVKPIENK EIVQAIVIAD SYNVNFEPFT SRKPLALLPI ANVPLIEYTL ESLNRNGVEE
VIVFCSNHID QVKRYIHQRQ IDRCTWSINM KVSIISSESC RSIGEAIRDL DARNTIRGNV
LLLGVDSLTN ANLAALLDEH KRLSKLDRGA VMTVVYKEGL RKMRTGNEVL IAMEPTTRRL
LYHQRLTQQE RERTFEVPLE LFLTNRDVAV CYGLLDPQIA VCSHAALPLF ADNFDFLTRD
DFVRGVLINE EILNSRIYVA KLAREEYAMR VNNWQSFHLV NLDVINRWLY PLVPDTAISE
FRQQYKHFRN NIYRHRNVRL SRSCELDGDL VVGEESEICE GTYLRQSVVG RGCRIGRNCR
IVNSFLMEGA VVGDGTVLNH CILERGVTVG EGCTINPGTV LGEGVEIPNR LVVTGLLLQA
SKPSDDEWAA PVQKIADHAY TIPVVDEDDS DSEEEDEKTG QPALNQPMMI APLPERYAPS
VYEPSDDECE SGPASPVPED ANIFLSEVIE SLKRGLSDRT NAEYLILEIN SSRYAYNMAL
CEVNYYVVKA ILQIMLQQDG VATNTVGTLR RLLAYFGVVF RNYIRDRDAM MDCLKAFEEM
CPANETLRTK IAQLVHYLYE QDLISEEVII EWYDALEDET IKTILSKLVQ WLQESSEEEE
EEEDDD
//
