ID A0A182R6Q3_ANOFN Unreviewed; 1590 AA.
AC A0A182R6Q3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=SAM domain-containing protein {ECO:0000313|EnsemblMetazoa:AFUN001851-PA};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN001851-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN001851-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN001851-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 62324.A0A182R6Q3; -.
DR EnsemblMetazoa; AFUN001851-RA; AFUN001851-PA; AFUN001851.
DR VEuPathDB; VectorBase:AFUN001851; -.
DR VEuPathDB; VectorBase:AFUN2_006836; -.
DR OrthoDB; 2905251at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20101; MBT_L3MBTL1-like_rpt1; 1.
DR CDD; cd20102; MBT_L3MBTL1-like_rpt2; 1.
DR CDD; cd20103; MBT_L3MBTL1-like_rpt3; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR002515; Znf_C2H2C.
DR PANTHER; PTHR12247:SF131; LD05287P; 1.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR Pfam; PF02820; MBT; 3.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00561; MBT; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51079; MBT; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51802; ZF_CCHHC; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT REPEAT 971..1075
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 1083..1182
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 1189..1290
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 1518..1582
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1383..1446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1388..1412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1590 AA; 175850 MW; E4CC49D500B5DA56 CRC64;
MSYQQVKNVQ STIVKPNPAP PGLPITNTTV LMPPTGGSSS TINDLKFFAG TTPTTATSGG
LRMYRPIAPK PAGTAGSSIL LSPTITISPT AAAMVTDGGM NSASGGIISN GVVPPSMVMQ
TVLPSHLQPT NHQQLEQPQQ SQPLYAGASK LVLPFGTTIK VTPPGMLNQQ QPLAAQSNVN
PQLLHQPLMH TPTVPVLQSL GTISIPKPPH QQHPQKLVLN ARLPIASTSA GTIVPTNIPP
LYVPPNKATL VATVANKLDG ETRRIMVTTG PVTNNSIIKR RVSLAPATTV EQQELRKPIK
AFPIPVLSPF KAQNIVQQQH LEQNIISEQN KDPVPVPLPS NAPHFVEQCG QKANVNLSLE
LENEPAAAVA PGTDDDELSN DDGSMLVMDL GETNAPEKKE GEKNMPFGAG MKRAAIIAQA
NGENLVEVDN DHELNDRAPL DEQSNFSNFE GLLPERNVSS QPEVPKTPEK APQEPGATGS
TSTNVSPRLQ KRSSSEHQPS KVKLCFSAIP QKNPNRRRFS EFALVRQPPT GVTIPFTDEH
YYIPLVANPR KMDPISLPMK NESNIKPTVA VEQNKSEHLV PQAPQPSSSS SSAQNVSLLC
NETIDVPKQI EEMLTKRPII PKQIKPVNEG GNELFQELVS LEEISRAKKQ RLAKENSLER
STNSRSTSMS SDSNVPAGKH APNTPLSESI KKSTSGSRGS GKKSSAASNQ ITPSESSASL
LDEGGVVYDT STVADHLRWY DGIGYLSESK MHFEFNKFGI VQPLSDEAYD RHCQTDVYRD
MQLRISERPL RTNERNAREA HDLYKCEVCQ KSGCAAEFVA PDYCSISCVQ ASSKHVLRDY
ILNSTHALQQ ANGLLKENNC FGGSVNRKVP VKAGQKQKNQ RPKKKQPTVK QNAKKATPSS
LTTASSTSDE DSMSSLSLNS SAFLKRQALR ELMPASLDDS PPPASAARSS GAAAAGATAS
PAIDGGEETE FNWNRYLKVM NAEAAPIHLF GPNPFPSLDT GSSANRFRIG MKMEAIDPEN
NSLFCVCTVA EVRGYRLKLH FDGYPNDYDF WVNANSIDIF PPGWCQKTNR VLQPPASYIG
QPFDWESYLQ ETNGLVPEND MFVHLNRKSD RNKFEIGMAI EADDLKKSGK VCVATVADKM
GDRILIHFDG WDNRYDYWVS IHSNYIHPVN WHRENNDKIT PPPDWNKPFD WEKYIRYKSR
NNLGPNSKAE KPLFKIRPPI YFKLGQRLEV VDRKQKKLIR PAKVVAIDGY EVSLCFEGWP
REYAFWIEDD SPDLHPINWC ARTKHPLEPP PNCLLSTGTF DGTCELKFCL SRGNSKFSQK
KFHDRSSECP YRRTNWMSED RKPLRVSHDQ VQTHNIEKPG GNSQNMKQIN ARNMLDVKAP
RKSMAVTAPN ASKASTARRR ASVTSVTPSP VPTKRIKQEV EEPPSTATST STPTPPPSRD
PSKERIVRVK ETEDMATAAS NHSTRATNAN ESIRLARPVI EEYGPRLMHS YEIWQRHSRY
LDECTEQTGV LRKNPLQWTT DEMARYIEQL PGCAEYASKI RHEEITGRSF LSFTQSDLID
YLGVKIGPAI KIYNRIIRLR QLVTTKFIQL
//
