ID A0A182R7D3_ANOFN Unreviewed; 609 AA.
AC A0A182R7D3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Poly(A)-specific ribonuclease RNA-binding domain-containing protein {ECO:0000259|Pfam:PF08675};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN002082-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN002082-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN002082-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR AlphaFoldDB; A0A182R7D3; -.
DR STRING; 62324.A0A182R7D3; -.
DR EnsemblMetazoa; AFUN002082-RA; AFUN002082-PA; AFUN002082.
DR VEuPathDB; VectorBase:AFUN002082; -.
DR VEuPathDB; VectorBase:AFUN2_003743; -.
DR OrthoDB; 276176at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR CDD; cd02637; R3H_PARN; 1.
DR CDD; cd12428; RRM_PARN; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034042; PARN_R3H.
DR InterPro; IPR014789; PolyA-riboNase_RNA-binding.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR PANTHER; PTHR15092:SF44; POLY(A)-SPECIFIC RIBONUCLEASE PARN; 1.
DR Pfam; PF04857; CAF1; 1.
DR Pfam; PF08675; RNA_bind; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
FT DOMAIN 440..517
FT /note="Poly(A)-specific ribonuclease RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF08675"
FT REGION 523..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 69742 MW; A5C6B818A1E61ED2 CRC64;
MDITKKNFIE QLPLIRETIR NATFFAMDCE FTGLASDRTI FPFDTPEEVY LKMVENSAQY
IIIQFGLCAF RVEPPAEEQK DAEPRLSYKC YNFFCYPKGR TNVFSCQGES IRFLADNGFD
FNRLFREGLS YANEIEEQRY RADLKERQAK RAATILAAAE DDSNESDSKA VETTDINAVP
VPAELQQQVE DTAASIEEFL QSDRPELIVG NCNAFQRKLI YQLIEQRFLR KVTTSTVSLE
NNQKAIKVER KRSLEEEQAL DEKRRAQENA DLEVNVGISL VLQELSKARK LIIGHNMLLD
LFYVLRQFFK PLPADYEEFK KLTKEYFPLL LDTKYLCTNA EIKVDVNSSV LAHVYDAVSK
APFAIPTVHA ELPDHQYSVD DEKKHEAGYD AYLTGLCFLG LVSRFKVNLL QLPKDTTLKH
YMNRIFITRL NDVNYIYLNG KEPSQSREHI FYVTFPENWR TTDIMSKFKP FGLVHVNWLD
NTSAFVSLHN RIVASSVLKT IGYHTGFKVY SFAQFTQMKL QRPATKRGRI GSGGPGRGNG
AEVRCGQPVD KPSGEEKAEE ERQEIDDSVT SAKRKGKHED QPPADNEADG GGWRTVKKAR
KTFTDNNDW
//
