ID A0A182RBA3_ANOFN Unreviewed; 496 AA.
AC A0A182RBA3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Ig-like domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN003467-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN003467-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN003467-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A182RBA3; -.
DR STRING; 62324.A0A182RBA3; -.
DR EnsemblMetazoa; AFUN003467-RA; AFUN003467-PA; AFUN003467.
DR VEuPathDB; VectorBase:AFUN003467; -.
DR VEuPathDB; VectorBase:AFUN2_005352; -.
DR OrthoDB; 2877710at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24270:SF61; CD320 ANTIGEN; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00192; LDLa; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}.
FT DOMAIN 132..221
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 291..457
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DISULFID 13..25
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 20..38
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 32..47
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 53..65
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 60..78
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 72..87
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 95..107
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 102..120
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 114..129
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 496 AA; 54919 MW; FDC37BCE72258DF4 CRC64;
MSRDTNQQSP DACSSNEATC MNGACIRKTQ ICDGNADCND GSDESSCSMY QRCEPNDFKC
RNSKCVFKTW LCDGENDCGD GSDEENCATL PDSPCRYDEF QCRSGQCIPK AFQCDTHPDC
PDKSDEIGCS PPSVIEPPPP SLTIPAGGIL NITCRAAGVP VPLIAWRLNL GHVPLKCESH
NDHGIGRLTC ENMQPIDSGA YMCEIINTMG THFVSPDTIV TVTGNGTMCQ QDTFNNKTRF
PADCIHCFCF GVSTICGRAN LYTHVLKPSY WPDAIVGTVG PWSGHDRLMV VDLGFYMLRR
VDDDMELILP NRHVNSLSPR HVSYCSYLKK YMGNQLNSYG GSIRYEVQYK GIDETVHAPD
VIIKGNGKVL VHWYKGTILT DVINHISVSL LPNKWQHMDD TQATREDIMM VLSNIELFLI
RMQYADKHPS AIKLMNVMMD SAAHDDRGLG SALLVEECSC PPGYRGLSCE SCEQGYVRQI
SEPWLGRCVL PDVKAA
//
