ID A0A182RDZ4_ANOFN Unreviewed; 1344 AA.
AC A0A182RDZ4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN004416-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN004416-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN004416-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 62324.A0A182RDZ4; -.
DR EnsemblMetazoa; AFUN004416-RA; AFUN004416-PA; AFUN004416.
DR VEuPathDB; VectorBase:AFUN004416; -.
DR VEuPathDB; VectorBase:AFUN2_009117; -.
DR VEuPathDB; VectorBase:AFUN2_011995; -.
DR OrthoDB; 1356373at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 6.10.250.780; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR013587; Nitrate/nitrite_sensing.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF08376; NIT; 2.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1059..1081
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 431..562
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 1137..1267
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1344 AA; 151522 MW; C05460DEAD4C66A7 CRC64;
MKSRVNHTDS SSIKSISSED VSTQQHYHGN MCCSAEAKNP AFKRGRQLQQ MQMIILPFIP
ILALIVQTSY EMIEIVSYRM EVTEIENQVT MATDLGKVVT RLQQERSDVA FYIYTNGITL
RRNLNDTFFE TDLALDNMSS WPDISIRTVQ PNNGEVTWLN MSEFRETLQE FRANISTEDS
TVPQILRWYT TANAALLEHL TNQIKDANKS GVWRFLLSFK NLLRSIESLD ISSVYGINYY
GRGYLKPDSY IKYVQHDILG RDLLNGSLHF VPSLKVIYRN ITLTMRSYGN ITQWSKTIQK
NLRREGNVAD ARSYYESMAY YIDELRKLQR ALRSIIRNEV QKVLQSADNM ETFGIAILVV
VLIVSPIIII LVRNAAATIQ LYAINLAHKA KELKREKRKS DSLLFQMLPP TVATQLKQAQ
TVPAEYYSAV TIFFSDIVGF TEIAAECTPL EVVSFLNAIY RMFDERIECY DVYKIETIGD
SYMVASGLPV KNGGNKHVAE IATMALDLLD ASGYFSIPHK ANEPVQIRCG IHTGPVVAGI
VGTKMPRYCL FGDTVNTASR MESTGEALKI HISAEMNEAL VKVGGFKTEH RGLIDVKGKG
LMDTYWLTCK EGATPNNSHG EVAWFADMKP VYLKIVIIVE RQLKHCNHIA TQIAYNRCTK
LERTQVTVHP PPDEPCVLTD KPTIVGLYPT GGGIGRRSRG PRCPFELDRL VAGTGGMPGE
LSRARDLSLK SSPSVATSTS RQSTSCSDVA LEREVTMYGC FKFNPSSRNA RKLFMTHMLI
VLLIPIASVV MQNMILLQQH VKSYSETVLA NEEMGLTINI TRLLNVIQHE RMSLVFYMLT
GKNRSQVERS IEITNDALSH LREDLNYLLP AGTANQTLIA DMRVNTPENE TFTGLEYFEP
YNALNRYVIN EIVRSTGTSI SSTVWRQFVV YKNLIEAIES INIAVILVLQ FMRNGYLDLS
DYAQFVRRDA AALDYIASAQ NFMTSLNIIS GEEFKVMQYW RNQVLINMSA AYRKDALMEY
YLSVTTILSN LQMVQDQIQA DVKETILEEI HSARKHQSIS IGLVVVIFII SPILVLMIRV
ATSTIQNYST KLMARTMELR MEKGKSDRLL YQMLPPAVVK QLKQQRQVPA ETFESVTIFF
SDIVGFTDIS ASSSAMEVVI MLNTLYRLFD SIILKYDVYK VETIGDAYMV VSGLPQRNGN
RHAGEIGMMS LDLVCGISGF TIPHMKNRTL EIRVGINTGP CVAGVVGTTM PRYCLFGDTI
NTASRMESTG EPMKIHISES TKEVLDKLGG FKIKLRGTVD VKGKGTMQTF WLTGHSLYEH
LTPDMLIPMY KQNVVTEPDF LQII
//