ID A0A182RL06_ANOFN Unreviewed; 1049 AA.
AC A0A182RL06;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=MI domain-containing protein {ECO:0000259|PROSITE:PS51366};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN006924-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN006924-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN006924-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the CWC22 family.
CC {ECO:0000256|ARBA:ARBA00006856}.
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DR AlphaFoldDB; A0A182RL06; -.
DR STRING; 62324.A0A182RL06; -.
DR EnsemblMetazoa; AFUN006924-RA; AFUN006924-PA; AFUN006924.
DR VEuPathDB; VectorBase:AFUN006924; -.
DR VEuPathDB; VectorBase:AFUN2_005923; -.
DR OrthoDB; 5491616at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR18034; CELL CYCLE CONTROL PROTEIN CWF22-RELATED; 1.
DR PANTHER; PTHR18034:SF4; NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51366; MI; 1.
PE 3: Inferred from homology;
FT DOMAIN 840..955
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT REGION 1..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..51
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..98
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..315
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..373
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..468
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1049 AA; 119952 MW; FF6B0273C54AF09E CRC64;
MKVRSRPPKN VRQGKVGRNG RNSKVVPQIK TRKDLRKEKR AQKKINRFNY HNRSRKERQQ
SAADNNFETN NKRGKYEQDN SEDEPEDFED EEIPSDFSDQ EEEAKPSAPP AKGKGKKNSF
ASQLDVDRAK EMKELRRYEE GLKSNRVKQL EAANEDDDRI IQKYEKLLKI NRRKNKEGVP
KSFNDGLDYA LELCTDDSIR KMYEAAKEAA ELEENSSDEF AEDLKQAIGG DLADEPMKSD
EQSSRTGKKR KKISPKEKHR VEKLKKIEEK YFGLDEMDDL GEYDSEMEIE RDDNVDDDYS
ENDELYDSDE DDSDGPQNEA DRKNAKRVKF ASGESTAKKN KKGKQPESDS EEEDDYDDDD
EFDDEESEDE DLSSSSSMLD GKKASKQSKK ETHDEGAGRF VLLKPNKDKQ SKNGKESGKK
DSKKAIKHKP TSDSEEEPSF DEDDEDDFGE EDDDGLDELL EDGGSDSDEL SNDEKKSPSN
DDGTWEDIYG RKRDKAGNII KEETAGGTGG KYVPPHMRAK LEAEEIAKGK SADPKQQEKL
QRLKRQLKGQ INRLAESNVH RISITLDNLY MQNSRYDMNS TLTTLILEAT VVPTLTPERM
VLEHMLLVAI LHANVGSEVG SHFLETIVER FLELHKRIET VANEAKELDN CVQLMCHLYT
FDIVKCKMVH EVMQKLIGCF NEKAVECILL VLRSVGFMLR KDDPLALKDL IITIQKKAAN
APDELKNDTR VKFMLETLLA VKNNNMNKIP QYDPTLVEHF RKLLKGMITS GKYVSTLNIG
IEDIINIPER GKWWLVGSAW LGNKELPSSA AAGTNASASA EGQYSAQLLE LARQQRMNTD
DRRNVFCIVM SAEDYLDAFE KLLRLAIKDL RVVVSVIIHC SLAEKEYNPY YSVLSQKFCD
FDRRYQLAIQ YALWDRLKEI HALQHQQQVR NLARFITHLI AEGGLALSCL KVIEFAEIDK
VNLRLMRQIM LGLLLLEDEN KCLQVFSRIS ASNKLKSFKD GIRLFMHHFL ARGSMSHGQL
PDEQVQLLQQ RIKQADELLS TDTKIEFDV
//
