ID A0A182RM65_ANOFN Unreviewed; 1186 AA.
AC A0A182RM65;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AFUN007337-PA};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN007337-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN007337-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN007337-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A182RM65; -.
DR STRING; 62324.A0A182RM65; -.
DR EnsemblMetazoa; AFUN007337-RA; AFUN007337-PA; AFUN007337.
DR VEuPathDB; VectorBase:AFUN007337; -.
DR VEuPathDB; VectorBase:AFUN2_012734; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:UniProt.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF122; INTEGRIN ALPHA-PS1; 1.
DR Pfam; PF01839; FG-GAP; 3.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1106..1130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 29..95
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 323..382
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 383..440
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 445..508
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 493..686
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 687..838
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 847..1095
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 102..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1144..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1144..1161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1186 AA; 128479 MW; DBE572426747C744 CRC64;
MAHLDVLGAM VASLVLLMFS SVTTFNLETR HLLDKRGLPG SYFGYSVAGH SQRRAAGNTT
TWMLVGAPLG QNLQPGSNHS GALYRCPITL ASNDCTQVIT DGHRTDDIDD EDGTGDSDNL
HEHRLEPPGK DEIKNNQWLG VTVETGGQEN KIFVCAHRYI KINNPQSLAY AASGPGSTGL
YLGQGVCYVL NEDFSFGFAV EVCRGRSIER EHQQYAFCQS GTSGAVLPDG TALIGTPGAM
TWKGTLFNVA IEGGFLSRDK FQYFAPHDNL HSPVPNYSYL GMSVTGGRFF GEYMAYAGGA
PRAAQGNGEV VIFANRYKKN PFDHVVSLRG EQFGSGFGST LASADINGDG RLDLLVGAPN
YFNRTDGGAV YVYLNRGSSF VQQYDQRLTG RLESRFGTAI ANCGDLNHDG LDDIAIGAPY
EASGTGRVYI HFGTKDGALS PEPVQTIDPT ELFANGGRTF GSSLAGGHDL DGNSYPDLIV
GSYASDRVNA LFARPIINIR TYEEQQPIEP SSIDPTRIGC TSDPTANVTC FTFQACSAVD
DASLNDGDVM ADSTLQLRCT IQAETFLKER KFSRVYFGTG VTPPGGNETG SNAASLSRTN
ILRRRFRLAV NGKPVCHEVT AYLKEGTRDI QNPIQFRISY TLDEEREHGR GGGRARSRME
RDLPRLEPIL NRTAAERTFT MPFQKDCGTD GICRSALAIH SAAVVGLTRG QSGSEAGNDY
QLVVGLDRTL TLALTVQNKA DSAYETHLYV VHDSSLTYAG SKGSSVCGAH NATVVDCSIG
NPLKRNGEVQ LSLRFDARSL EEYGYSNGPN GITHTVGMAV FVNTTSQDTG SKTRTALNLH
IQRVAKVSMS GKALPEQVFY GSGDAQVMGE SAIHSLDEIG MSVEHKYQAS IYNDGPWRAP
YVRLEIDWPL QVANNKPQGK WLLYLDALPM LDMSGIMGDG RSPCEVLPKN EPDGAVVPSN
AASLVNPLGL PDGAGSTARS QMRSNYTQMR AQRMRRDRAM VLRPQTTDGA VQMDCASQTA
KCVRIVCKIH DLGPKAHALV TVTARLWNAT LVGDYAHVDL VRIGSNARFT VEGLDELVDQ
SQHPTSLTVR TEAFPEMGPP IVAMNVPWWI ILLAAIAGLL VLIAVTYILY RCGFFRRKRH
TGEDPTLSGN LERRRDPTGG AYDELNDTNG SGGGTAERKP FLGRRS
//
