ID A0A182RP81_ANOFN Unreviewed; 1815 AA.
AC A0A182RP81;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 13-SEP-2023, entry version 26.
DE RecName: Full=Rapamycin-insensitive companion of mTOR {ECO:0008006|Google:ProtNLM};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN008064-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN008064-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN008064-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RICTOR family.
CC {ECO:0000256|ARBA:ARBA00008878}.
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DR STRING; 62324.A0A182RP81; -.
DR EnsemblMetazoa; AFUN008064-RA; AFUN008064-PA; AFUN008064.
DR VEuPathDB; VectorBase:AFUN008064; -.
DR VEuPathDB; VectorBase:AFUN2_012152; -.
DR OrthoDB; 90320at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR028268; Pianissimo_fam.
DR InterPro; IPR028267; Pianissimo_N.
DR InterPro; IPR029453; Rictor_IV.
DR InterPro; IPR029451; RICTOR_M.
DR InterPro; IPR029452; RICTOR_V.
DR PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR Pfam; PF14663; RasGEF_N_2; 1.
DR Pfam; PF14666; RICTOR_M; 1.
DR Pfam; PF14664; RICTOR_N; 1.
DR Pfam; PF14668; RICTOR_V; 1.
DR SMART; SM01303; RasGEF_N_2; 1.
DR SMART; SM01307; RICTOR_M; 1.
DR SMART; SM01308; RICTOR_N; 1.
DR SMART; SM01310; RICTOR_V; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
FT DOMAIN 95..489
FT /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01308"
FT DOMAIN 663..888
FT /note="Rapamycin-insensitive companion of mTOR middle"
FT /evidence="ECO:0000259|SMART:SM01307"
FT DOMAIN 1074..1148
FT /note="Rapamycin-insensitive companion of mTOR"
FT /evidence="ECO:0000259|SMART:SM01310"
FT REGION 205..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1170..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1405..1434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1559..1581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1593..1612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1629..1711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1815 AA; 200238 MW; D406435B1DAA4CD1 CRC64;
MAMSSWMIRR SLRQRNRPAP EDCYRLDTDK TLRENATDIY TGLCSIHTTV NKRLSLLNGL
VKLIDRWKRD AGLDSGASRD SSAPQSSRSV ALHSAGRDAS LGYTVQQWMC CIGRSLVHQL
PQIRAGALRA LRRLLLAPCD MRELNRLQLA HLVCRSLDVM LRNGEERIQA LKLVRRMLVV
APDELRPAIV RCLVALCESG TAGTGTTGPG GGGGTGGGPG GGAGGGGHAG GSGEDRLLRC
CLATLCEIGV LNPLLLIECG GVGVITRSVL ECHSPRIAES LCGVLLYLLE WPRTRDIAGV
RLDCFAAPYC DFTYRVGIMD RYKDARELRF TCSRLALLSV LRSWAGTIEF CDPHRPSGLR
SLIDILYLNQ LEIRKAVLDL LYELIGLPQP VWTDEYSVAM SVVDPAEYQD AWRLHEGFVA
AEGTAILPSL AGAVPNLCEI HLALLLYCFV ENGLLNALIE VIISSDTFIS VRATILLARI
THQLHCLLPA EICARTPTAT LPMLVTRAIE GNHQARAAIT ALQQHHLMLQ NRPASCSLYL
DCIIQSGELI NTRAFRRELV APGNRTGQQG NGYGVGGPNA YKYGTLDGLK RVRHDSTGSS
GGSGGLGGLF GNMFLSGGSG SGGAYEWNTS YDGSFVRDVT RGTMRSGTMK RTSKRNVLQQ
LWASLTEGDR LLKESNVLAV KDANMWDWDI IITILRSDLL GMKLDEQNTR FVRRIVDYFK
PSNNRFSHQD FAHLNSNRQM PAYVTAGLEL IDAMLQSTEL EYIRILTDLF TDISRQLMAI
HAKKSAHECL FSPLHMTGTM CQHYFLFIGR MCRTEGGLEI LRNTDVFKEL STIVLKTNHL
CYVKLIVSGL DYSLEGEPRL ILAKALLRHP SPKARLYATQ MLRVLLRARL PNFEVWGIQL
MLKLVAAMLG DGQTRCVQMA ALDLLEEACY ERTYLEELAH SWPRLDRLGP RGKMVMMRFY
SIPRGINHPE AHTVQELEQW VTVYNEQYVL LVESDTHAHL TQHIRTEDGT YSRRHIANGA
PGESTAAGAP NLAPHLYGQL VQTSKGFSQL LNHGSLVELA ERVRNGVCNN EQDCLRLKAA
LWALCHTCTS KEAIEYVNEH LPWLLPHLVQ LVRTADVYSI RATALGGLCL VASTAQGADA
LRAMGWVAVR HDRNTHWPVN EPGCWETAVP AASSASTNES DGEGPGRRRH SFASTEDEST
ANSVSFLASS CLVTGDLSPI PSTSHPSSVE REVINGRKQH RHLFHVRRPL LSSSSADMTD
AEDVPMQLDN SERLFSFFRT STVTEPVDYG GKIRSLDRKY HRLSLQHYSL SEDGHYPSVK
AKSSFFPIKT NTQGPCFIGI CFPLDIMELF PELETRRPLA LGSLVQLDRS KMRSKDSGRS
MKVVKLRVKT GSDVDEGIAV DYEQEMKGGA PPNAPAPCSP ASSNHDESES GDGRQQWWSY
EKHNRSQCVR CCRGKRAEDR WNPADLDDSG RPVLDDAIAN NVLRHVQRMA NPVWSKQSRS
VLLDIKQSHP YVFQDVCLYS EVCRLLGCNT YRLGSRRFLQ ELFLDLDFLG PCKTTTPVEV
PSVPQHTTQH NTAPPPTTSK ALHTPLQIQT QNLPAPGTIP GGTKSPLPGG LSAFLLRSPP
LASVHEASVE NLDEMSTTPK QRDSVRTGQQ EPFPATVRDP PRQQSGVTTA DDELTTVRLR
DPHGTSTMPP PTTAHHHRPR SIGAQSGSGM MEPVRPRFNT LELDLSCSRN KFPIRDRSKL
DYSPTTPPVA YGTGTALPLS ASSSSASFIS TGSASAVTSP TQGVPGASVT FYNLFCEQRL
RLKSSKSEAT LTKNP
//
