ID   A0A182RQ97_ANOFN        Unreviewed;       521 AA.
AC   A0A182RQ97;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 2.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Cytidyltransferase-like domain-containing protein {ECO:0000259|Pfam:PF01467};
OS   Anopheles funestus (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN008439-PA, ECO:0000313|Proteomes:UP000075900};
RN   [1] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA   Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA   Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA   Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT   "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT   Middle East: occurrence data, distribution maps and bionomic precis.";
RL   Parasit. Vectors 3:117-117(2010).
RN   [2] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA   Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA   Besansky N.J.;
RT   "A chromosome-scale assembly of the major African malaria vector Anopheles
RT   funestus.";
RL   Gigascience 8:0-0(2019).
RN   [3] {ECO:0000313|EnsemblMetazoa:AFUN008439-PA}
RP   IDENTIFICATION.
RC   STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN008439-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182RQ97; -.
DR   STRING; 62324.A0A182RQ97; -.
DR   EnsemblMetazoa; AFUN008439-RA; AFUN008439-PA; AFUN008439.
DR   VEuPathDB; VectorBase:AFUN008439; -.
DR   VEuPathDB; VectorBase:AFUN2_003461; -.
DR   OrthoDB; 460288at2759; -.
DR   Proteomes; UP000075900; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:InterPro.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.
DR   CDD; cd02022; DPCK; 1.
DR   CDD; cd02164; PPAT_CoAS; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR001977; Depp_CoAkinase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR   NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR   PANTHER; PTHR10695:SF64; BIFUNCTIONAL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR   Pfam; PF01121; CoaE; 1.
DR   Pfam; PF01467; CTP_transf_like; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51219; DPCK; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          153..293
FT                   /note="Cytidyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF01467"
SQ   SEQUENCE   521 AA;  58331 MW;  AC1BE6FB1F1BF5C7 CRC64;
     MPSRTGLLTA VHLANIAKTL SATRPYALNT LYLQFHPQVA ANVSCPLALG RFVASVYQSS
     VTWLGSEVDL RIVTGSLRST GASFESFANR TRPATVDYLF YDYALSSSSA SCEKRLVERY
     PGVKVVELDT LGLDDFKLPA DLDNSLKTYR NVVLGGTFDR IHAGHKVLLT QAVLLATERV
     VVGVTDGAMI KSKKLHELIM PATQRIKHVT EFLEDIDPFL SYEVVPILDP FGPTATDPNM
     DLIVVSTETA RGGAKVNELR KSNALNQLEV YTIELLDDES TIEDKEDKIS SSNQRMDLLG
     TRLRPRKPAP AHIPSKPYII GMIGGIAAGK SKMLERFQDF GAGIIDCDKI GHQLYEPGEE
     CYQQVVTTFG KEIVHPDGTI NRKALGAIVF ADQSKLDQLN EIMWKAIAKR ANEQIRTLHE
     QHGKDVIVME AAVMLRAGWQ NNCHEVWSCI VPREEAIRRL MERNQLEEQD AIRRVDMQPT
     TNEEMVQHSD IVFCTLWSYE YSQQQAEKAW SIVQQELKLK L
//