ID   A0A182RT41_ANOFN        Unreviewed;       362 AA.
AC   A0A182RT41;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 2.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=RNase H domain-containing protein {ECO:0000313|EnsemblMetazoa:AFUN009442-PA};
OS   Anopheles funestus (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN009442-PA, ECO:0000313|Proteomes:UP000075900};
RN   [1] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA   Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA   Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA   Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT   "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT   Middle East: occurrence data, distribution maps and bionomic precis.";
RL   Parasit. Vectors 3:117-117(2010).
RN   [2] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA   Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA   Besansky N.J.;
RT   "A chromosome-scale assembly of the major African malaria vector Anopheles
RT   funestus.";
RL   Gigascience 8:0-0(2019).
RN   [3] {ECO:0000313|EnsemblMetazoa:AFUN009442-PA}
RP   IDENTIFICATION.
RC   STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN009442-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182RT41; -.
DR   STRING; 62324.A0A182RT41; -.
DR   EnsemblMetazoa; AFUN009442-RA; AFUN009442-PA; AFUN009442.
DR   VEuPathDB; VectorBase:AFUN009442; -.
DR   OrthoDB; 3135817at2759; -.
DR   Proteomes; UP000075900; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR   CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00075; RNase_H; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
PE   4: Predicted;
FT   DOMAIN          175..303
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
SQ   SEQUENCE   362 AA;  41907 MW;  63D08A8251560FA8 CRC64;
     MYTRYELWVT LYRKFLNHLK EYCSCSTHSL APSLDNRCVI RGMHSGTDGW HMYRNALLLE
     YRKHRQRLAK REQLELAREM IAAREIAQHC RSNNRTYSEL RELEALDNGR PLSFVQRIFL
     ENRYIFEAIA KHIRTAELLT DVRVNPSLEQ LNVGKCNLQP ETLRRLTEYV LESEYCGLVH
     IYTDASKSPD GQCGIGVYDE TNEVRIAVQL KLDTSIMTAE TLAIKVAMQH IAERSIHRAV
     LLTDSQAACT FLKKNRNSRY RNAVANEILE LARTFQVAIQ WIPGHVEVSG NQIADELSRA
     ALANGTERLE NDIFIHDAIS YFEERQASKI NKWYQEYIRL KGKSLKQLCG EDDDSAHSYY
     AL
//