ID A0A182RU23_ANOFN Unreviewed; 1415 AA.
AC A0A182RU23;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Rab-GAP TBC domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN009776-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN009776-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN009776-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 62324.A0A182RU23; -.
DR EnsemblMetazoa; AFUN009776-RA; AFUN009776-PA; AFUN009776.
DR VEuPathDB; VectorBase:AFUN009776; -.
DR VEuPathDB; VectorBase:AFUN2_007936; -.
DR OrthoDB; 2908929at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR CDD; cd01211; PTB_Rab6GAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219:SF9; GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B; 1.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 417..495
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 847..1033
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 1..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1093..1145
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1255..1282
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1211..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1415 AA; 154369 MW; C9850D19055849F7 CRC64;
MEKQSDWANI SSSSTPIGEA RTKQNVTASA ASKKEGGVTG AGVNSTKPEK NTHPDSTSGN
GGASPVQLVE PSAGGTTDPT VGPKSEDSVS IKSSDSVTTS GEYEIVPEAP SPGEDLVDSG
ATPRPKQLAS EPIRNTEANG NAGVDIGADL AECIADAGEA EGKEGKETAK KRTEGKKLSA
ISPILNIEGN GNMMDLEKNM NEVIHELDEE RTLSGASEPS SSNKATPVRS PEKRDTAESN
SQTPQHGADG GGAKKPPVPT TLRLGLQSMR ANFTIGGGEG STDTTPNALL SPEGIGRGVG
QSVFYDCLDS SPLTEKKDDM KPVGGCGVGA AAAGGETDDE LSDIDQDCTI FSGVTYLGAS
RINAPKSERE ILQKVTEMNG GGVGVGGVGG SSTGTGSDSP LGLKVSVSVP TCSEGLVVLY
DCESHAVVAT YEVQRILFFA RGPVGTTDQA CFAFTWSHGE SQETAVHQCH VFRCNIPEAV
TQVSTCFAKA FQRVLPPSIP ASMTTSLAES GVNLMLASVT SDTAGNPIQS PMFEFAVSLE
IKEKERNGTY VTVPRDVKSS FRLRCKTDKE LCITVRQLPS DRFPFLLIDR CFGVLLSPGR
IVRQADMQLL DMVDAKYVKP LDGNPSAPGT GNSSTGANVA CNSSNSNVTD PANPYQIKAE
WKANAFEALN METPKKALTV AVNLVINGIE EPVQFVIETS VAILSQSELR IVSNMFTNKR
PLLLHFYLTL RKNGKGTWEV DSIDHSDEIV EAQAPSATSS LSLNFNFKNW TFRNSASVQS
MQDFDDPSPT DYSSDGDEPL LSGTGEVSRI CTTAQQDEWD VILKEWYQEG SAPEKRPKNL
PNLVRMGIPE MLRGKVWQRL ACVENRNEMF DSYRVLITKE SSCETVIQRD INRTFPAHKS
FKENGGTGQE NLYKVSKAYA VYDTEVGYCQ GLSFIAASLL LHMPEEEAFC VLVALMYNYG
LRDMYKMGFE SLYLRLYQLN RLMKDQLPDL YEHFVQMGVE SHMFASQWFL TLFTARFPLY
FVFYILDVFL LDGIPVLFQV ALTLLSVCRK DLLELDFEGI LKYFRVTLPK KCRNETQAQK
LMKLSFECKV KKLKKYELEY LAKKEETERK EQELKQYKQR YGEERDKLQQ EIGLLNDKID
SMAREDRKNV GIIQDYKRII QRQEAENGKL HTMLDDLTKT ISTCSKCTAS IPQSSPLHKS
YGKNFQQANT VNNNNEQQNH PLADQPDGGS STGTGGGKQA GASAVIGGLG PLDPLVIASQ
RIRELELELA QTKLAQVEAE CKNQDLHHQL NTTVTELQAT RSSWQPWLSK TLNSIQEKVV
TKRDVNPPAP TFQSYASTDG NIKNHSNTLP HVRNNNNKAA LAQRHSLAQV NFSGSDCTTA
SDADGNGGDP QVLARAKYDS SVNILYKDTR CNSLK
//
