ID   A0A182RUZ0_ANOFN        Unreviewed;       904 AA.
AC   A0A182RUZ0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|SMART:SM00913};
OS   Anopheles funestus (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN010100-PA, ECO:0000313|Proteomes:UP000075900};
RN   [1] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA   Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA   Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA   Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT   "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT   Middle East: occurrence data, distribution maps and bionomic precis.";
RL   Parasit. Vectors 3:117-117(2010).
RN   [2] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA   Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA   Besansky N.J.;
RT   "A chromosome-scale assembly of the major African malaria vector Anopheles
RT   funestus.";
RL   Gigascience 8:0-0(2019).
RN   [3] {ECO:0000313|EnsemblMetazoa:AFUN010100-PA}
RP   IDENTIFICATION.
RC   STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN010100-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-2
CC       subfamily. {ECO:0000256|ARBA:ARBA00038423}.
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DR   AlphaFoldDB; A0A182RUZ0; -.
DR   STRING; 62324.A0A182RUZ0; -.
DR   EnsemblMetazoa; AFUN010100-RA; AFUN010100-PA; AFUN010100.
DR   VEuPathDB; VectorBase:AFUN010100; -.
DR   VEuPathDB; VectorBase:AFUN2_003426; -.
DR   OrthoDB; 276400at2759; -.
DR   Proteomes; UP000075900; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527:SF3; FI21453P1-RELATED; 1.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          31..99
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00913"
FT   REGION          326..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   904 AA;  102197 MW;  34965325D9A3F5B3 CRC64;
     MSWEPQPDGL SQIITLLKQS QSKDNMVQRA VQLKLEELNQ YPDFNNYLIY VLTKLTSENE
     PTRSLSGLIL KNNIRIHGAQ LQPAILEYIK QECLMALSDP SPLIRATAGI LITTIANTGG
     LQNWPELLPT LCDMLDSQDY IVCEGAFGAL QKICEDSADT LDSSALNRPL NIMIPKFLQF
     FRHSSPSIRS YAIACINQFI VNRTQALMVH IDTFIENLFH ISSDDDREVR KNVCRGLVML
     LEVRIDRLMP HMNNIIEYML VQTQDSDETS LNACEFWLSL AEQNICKEVL TPHLPRLVPV
     LVRGMKYSDI DIMVLKGDVE EDEMIPDREE DIKPRFHKSR TVTQKPSIGA GASGSDSAVR
     SMEGNDDDDD IDDPYVDMND DSNPSDWNLR KCSAATLDVL ANVYKDEFLP ILLPILKETL
     FHEEWLVKES GILALGAIAE GCMTGMVPHL PELIPYLIVC LSDKKALVRS ITCWTLSRYA
     HWVVSQPHDQ YLKPLMKELL KRILDANKRV QEAACSAFAT LEEEACTELV PYLGFILDTL
     VFAFRKYQHK NLLILYDAIG TLADSVGHHL NKPEYISMLM PPLIEKWNNL KDEDKDLFPL
     LECLSSVATA LHSGFLPYSE PVYRRCISLI QQTLIQDVAS TTNPTQFEQP DKDFMIVALD
     LLSGLAEGLD CYIESLVSSS NIMQLLFQCM QDSMPEVRQS SFALLGDLTK ACFQHVHPHI
     ADFLPILGHN LNPEYISVCN NATWAIGEIS IKLMEDTKPY IPMVLGPLIE IINNTNTPKT
     LLENTAITIG RLGLVCPVEV APSLQQFVRQ WCSSLRNIRD NEEKDSAFRG MCQMITVNPV
     GVVPDFIFFC DAAASWMTPQ KDLHEMLQKI LHGFKMQVGE ENWSRFVEQF PPQLSERLAV
     MYSI
//