ID A0A182RWN8_ANOFN Unreviewed; 1156 AA.
AC A0A182RWN8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 13-SEP-2023, entry version 27.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN010698-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN010698-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN010698-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A182RWN8; -.
DR STRING; 62324.A0A182RWN8; -.
DR EnsemblMetazoa; AFUN010698-RA; AFUN010698-PA; AFUN010698.
DR VEuPathDB; VectorBase:AFUN010698; -.
DR VEuPathDB; VectorBase:AFUN2_011576; -.
DR OrthoDB; 2956716at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR CDD; cd21205; CH_LRCH; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF21; CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50021; CH; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 577..695
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 163..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..754
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1156 AA; 124613 MW; EBD55E8ABF67852E CRC64;
MEKLTELDAA CNQITHLPSR MGDLRNMRSL NLRSNQLVYL PRDLTCLQLA FLDISSNKIA
TLPVELRHMT SLVDLELSNN PLTSPPASLC VRGLVHVFKY LETIASREEK SKTGVDGHAT
LRRTALSAKN SNSCLLDNQQ RNRRAHVDSG YCTSDGGFDG KRWMHDEDTH NSATASSKWS
PTPLHSGFTV MPRNGSNHNT TSNPSSGGPQ AVLVAHAMHG GSNDPAVDST VGTIGGNNDV
CWEEEFRKNA AFQDLHPDRK QLSNNNSNDI SPEGDITPDG TKTDEKGRTL SNYQTYREYK
EALRQQRNLD SVYRSKDHPL TPDSAGSATE SPVSNVSPYT KSISSSSVYS SSSQSSPVSP
HHTTGVQKMN QMNANPNGMY NTTGTTGAHS SPLLSPNRNG GQPSTTDDNT GGTPNKRPVQ
KVIPSRNIGS SHHSQSPTHL NGNLHASGMA STSVSNGSHG KIPLANGAGK GSLSSPNGSV
SNEYAYVKPN SPCKSTSGAL THNNVPPSSI PKPMAPNGGG GLGSPVLAGG SQKPLTATVG
YVNNAKPGQK TNKTVSWNRD VPTEKLSFTM RREFDKQKEE TELIEQLRQI IETRLKMSLP
QDIAPALMDG VVLCHLANLV RPRSVGSIHV PSSAVPKLTM ARCRRNVDYF LDACRKIGVD
EELICSCQDI VPSTMAEPPL EDSDRKAKYD DGHGSQEACL AARPPNPLAM YRTIAALLSM
PPISSQLVAP PSPSAIGLLR RPRSPPPPPP PSASHSVTAV TAAATNTNSS TAPENNLNCY
PMTSHDISAL GTIESQSLKI VTQLTATDEI LEYSHSEYNA KSHHGNEDYR NVPVTLDLPK
GNAKPGRKRK FPSSRTGRRN HSSNDIQSNL NEIIEECEYD SDIGKFRCRT NDSDDMRYDL
RDYEDSETSL TSCDDDLIGV EAVGDENGDA FTPTNAQPTM GESLICRQVS SNDLDTPILS
LKSMKPETKG NENFNIVQND NDSLPVEEQK VVTKRIEFFE NAASTGRKIL NCESPNVASV
GVSAAVEHKA VEVKDVSEEK DSQLNAIVEN RRHESDHPMI STILCLGTFL FTNLLCCAAD
VLEGRGIVQV AITVVELLKF YNPASNVRSP TRNMYAIGNN YNSGGSSGSN SSNGSNVPKS
SPSNSSLSSP VSGNGT
//
