ID A0A182S643_9DIPT Unreviewed; 903 AA.
AC A0A182S643;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
OS Anopheles maculatus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; Anopheles maculatus group.
OX NCBI_TaxID=74869 {ECO:0000313|EnsemblMetazoa:AMAM000399-PA, ECO:0000313|Proteomes:UP000075901};
RN [1] {ECO:0000313|Proteomes:UP000075901}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=maculatus3 {ECO:0000313|Proteomes:UP000075901};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles maculatus species B.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMAM000399-PA}
RP IDENTIFICATION.
RC STRAIN=maculatus3 {ECO:0000313|EnsemblMetazoa:AMAM000399-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A182S643; -.
DR EnsemblMetazoa; AMAM000399-RA; AMAM000399-PA; AMAM000399.
DR VEuPathDB; VectorBase:AMAM000399; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000075901; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 266..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 878..901
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 261..426
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 903 AA; 100621 MW; 0391B23A86771625 CRC64;
MGMGINFLRV TTNPVELWAS PYSRSRVERE YFDSNFEPFY RIEQIIIKAE NLSNVMHNTS
NGVIQFGPVF NRQFLLDVFD LQEQIKKIVA VRDDGSNKTI GLKDICFAPL SSSSGPQDTQ
ECVVQSLWGY FSDDMDNFNE EEEDAQGFVI NYLDKLIQCF GNYYNPACLA PYGGPIDPAI
ALGGIPQPKS PDEKASYTEA NAVILTFLVR NYHDKNKLQS ALAWETEYVS FMKNWTRENM
SIAFTSERSI EDELARESQS DVSTILVSYI IMFAYIAISL GHVNQWKRAL IDSKVTLGLG
GVAIVLASVV ASVGIFGYIG VPATLIIVEV IPFLVLAVGV DNIFILVQTH QRDTKKPTET
HAEHIGRILG RVGPSILLTS VSESCCFFLG GLSDMPAVRA FALYAGMALL IDFFLQITCF
VSLLALDTIR QADNRLDVLC FLRGSKKDMP GSIGEGLLYK FFKSVYVPFV MRKPVRVAVM
IVFFGWLCSS IAVAPHIDIG LDQELSMPGD SFVLKYFRYL QQYLSIGPPV YFVVKNGLNY
STMHDQNLIC GGQYCNLDSL STQVYIASKQ PQSSYLARPA SSWLDDYIDW SAAPGCCKQW
TNGSFCPHQK SACGMCNITL TPQKRPAEDS FRHYVSFFLE DNPDEACAKA GHAAYGSGVK
YRPDTLSPLY NDVGASYFMA YHTILKSSSD YYEALRSARK ISANITSTIQ ANLRLQGRSE
ADIQQIEVFP YSVFYVFYEQ YLTMWPDTLK SMGISVLAIF IVTFLLMGFD IHSSLVVVIT
ITMIVINIGG LMYHWNISLN AVSLVNLVMA VGISVEFCSH LVHSFAMSVE ETREKRAADA
LTKMGSSVFS GITLTKFGGI LVLGFAHSQI FQVFYFRMYL GIVLYGAAHG LVFLPVLLSY
IGE
//
