ID A0A182SCD0_9DIPT Unreviewed; 1599 AA.
AC A0A182SCD0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Myosin motor domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles maculatus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; Anopheles maculatus group.
OX NCBI_TaxID=74869 {ECO:0000313|EnsemblMetazoa:AMAM003933-PA, ECO:0000313|Proteomes:UP000075901};
RN [1] {ECO:0000313|Proteomes:UP000075901}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=maculatus3 {ECO:0000313|Proteomes:UP000075901};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles maculatus species B.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMAM003933-PA}
RP IDENTIFICATION.
RC STRAIN=maculatus3 {ECO:0000313|EnsemblMetazoa:AMAM003933-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EnsemblMetazoa; AMAM003933-RA; AMAM003933-PA; AMAM003933.
DR VEuPathDB; VectorBase:AMAM003933; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000075901; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR031732; DUF4729.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692:SF33; MYOSIN; 1.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR Pfam; PF15866; DUF4729; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 207..877
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1153..1389
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1394..1599
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..778
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1086..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1029..1059
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 300..307
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1599 AA; 184957 MW; F340DB30638BC4C9 CRC64;
MQRAKHLKTP TNTNQESTRN LPKSNSITPA QCPLPGCDQS VMASNLLQHY LRDHSNLSFI
SIEDRETMLF HFEESAFPLN TPYCLGVLAY GGRQPEHHPV REGYAVENQF LPQRFKSLKN
YLPVLVMGCR TTRFGDAESV LQGDHDEEKR GDYIWIEPVS GREFDVAIGA RVISAEGRRI
QVRDDDGNEQ WLTPERRIKA MHASSVQGVE DMISLGDLHE AGILRNLLIR YNENLIYTYT
GSILVAVNPY QILPIYTADQ IKLYKERKIG ELPPHIFAIG DNSYAHMRRY GQDQCIVISG
ESGAGKTEST KLILQYLAAI SGKHSWIEQQ ILEANPILEA FGNAKTVRND NSSRFGKYID
IHFNSAGVIE GAKIEQYLLE KSRIVSQNAD ERNYHIFYCL LAGLSPEEKR RLDLGQASDY
RYLTGGGCIR CDGRNDAAEF ADIRSAMKVL CFSDHEIWEI LKLLAALLHT GNIKYNATVI
DNLDATEIPE HINVERVANL LEVPLQPFID ALTRKTLFAH GETVVSTLSR DQSMDVRDAF
VKGIYGRLFV LIVKKINQAI YKPKSSTRSA IGVLDIFGFE NFDHNSFEQF CINFANENLQ
QFFVQHIFKL EQEEYNHESI NWQHIEFVDN QDALDLIAIK QLNIMALIDE ESKFPKGTDQ
TMLAKLHKTH GTHRNYLKPK SDINTSFGLN HFAGVVFYDT RGFLEKNRDT FSADLLQLIS
SSTNKFLQLV FAEDIGMGAE TRKRTPTLST QFKKSLDSLM KTLSQCQPFF IRCIKPNELK
KPMMFDRALC CRQLRYSGMM ETIRIRRAGY PIRHNFRDFV ERYRFLINGI PPAHRTDCRM
ATSKICATVL GRSDYQLGHT KVFLKDAHDL FLEQERDRVL TRKILILQRS IRGWVYRRRF
LRMRQAAVTI QKYWKGYAQR QRYKKMRIGY MRLQALIRSR VLSHRFRHLR GHIVRLQARI
RGYLVRREYG HKMWAVIKIQ SHVRRMIAMK RYHKLKLEYR RHHEALRLRR MEEEELKHQG
NKRAKEIAEQ HYRDRLNEIE RKEMEIELEE RRRVEVKKNI INDAARKADE PVDDSKLVEA
MFDFLPDSSS EAPTPHGGRE TSVFNDLPVN AGSHDDIIGP IHTISEEDEE DLSEFKFQKF
AATYFQGNIT HYYSRKPLKH PLLPLHTQGD QLAAQALWIT ILRFTGDLPE PRYHTMDRDN
TSVMSKVTAT LGRNFIRSKE FQEAQMMGLD PEAFLKQKPR SIRHKLVSLT LKRKNKLGED
VRRRLQDEEY TADSYQSWLE SRPTSNLEKL HFIIGHGILR AELRDEIYCQ ICKQLTNNPS
KSSHARGWIL LSLCVGCFAP SEKFVNYLRS FIREGPPGYA PYCEERLKRT FNNGTRNQPP
SWLELQATKS KKPIMLPITF MDGNTKTLLA DSATTARELC NQLSDKITLK DQFGFSLYIA
LFDKVSSLGS GGDHVMDAIS QCEQYAKEQG AQERNAPWRL FFRKEIFAPW HNPIEDQVAT
NLIYQQVVRG VKFGEYRCDK EEDLAMIAAQ QYYIEYSTDM SMDRLYTLLP NFIPDYCLTG
IEKAIDRWAA LVLTAYKKSY YLKEKAAALK VKEDVVSYA
//
