ID A0A182SEN1_9DIPT Unreviewed; 432 AA.
AC A0A182SEN1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=TNF family profile domain-containing protein {ECO:0000259|PROSITE:PS50049};
OS Anopheles maculatus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; Anopheles maculatus group.
OX NCBI_TaxID=74869 {ECO:0000313|EnsemblMetazoa:AMAM005247-PA, ECO:0000313|Proteomes:UP000075901};
RN [1] {ECO:0000313|Proteomes:UP000075901}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=maculatus3 {ECO:0000313|Proteomes:UP000075901};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles maculatus species B.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMAM005247-PA}
RP IDENTIFICATION.
RC STRAIN=maculatus3 {ECO:0000313|EnsemblMetazoa:AMAM005247-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR AlphaFoldDB; A0A182SEN1; -.
DR EnsemblMetazoa; AMAM005247-RA; AMAM005247-PA; AMAM005247.
DR VEuPathDB; VectorBase:AMAM005247; -.
DR OrthoDB; 5403423at2759; -.
DR Proteomes; UP000075901; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514}.
FT DOMAIN 282..342
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..31
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..85
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 48837 MW; 137FB68899217E5E CRC64;
MCLARSFDNE LFDSPDEYMY EPEDLDTDVS DDGQREPETN ESGLSSSGMR DEDEDQEDSE
EKENLGIEDL RETNDDDDND DDDLIIDDRV EIGVAGGMRR ARSISGVTRQ GVPIVDEPYV
PRRNRTRHPH RIFEQLRQRP EELVTPPTSG EMFRWDVENR KTHTASRHQS YGSISIRPYQ
HEAHNLREHH STTPMPVAYG SHAGLHAGNP TKPPPQILNR MSRVQATGES MRKQLQQTQR
FPKVVGNPGT QKEIVMAPES RVRLRQRKGG AVQPVEPVAK GVHLVELSDK GPVQIDTRYQ
EWSANDNASK QAIQSPSFDF DGEHLTVNEP GLYYVYAQIT YSNEFDANGY KVLINGRKHL
SCTVHTTQGE NTNTCFTAGI AEIANPGTRI SIQDVDHGRH HVMFPEKTFF GAFKIGRLAT
PTVTHRRARK VT
//
