ID A0A182SFG0_9DIPT Unreviewed; 832 AA.
AC A0A182SFG0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Potassium channel domain-containing protein {ECO:0000259|Pfam:PF07885};
OS Anopheles maculatus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles; Anopheles maculatus group.
OX NCBI_TaxID=74869 {ECO:0000313|EnsemblMetazoa:AMAM005734-PA, ECO:0000313|Proteomes:UP000075901};
RN [1] {ECO:0000313|Proteomes:UP000075901}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=maculatus3 {ECO:0000313|Proteomes:UP000075901};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles maculatus species B.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMAM005734-PA}
RP IDENTIFICATION.
RC STRAIN=maculatus3 {ECO:0000313|EnsemblMetazoa:AMAM005734-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR AlphaFoldDB; A0A182SFG0; -.
DR EnsemblMetazoa; AMAM005734-RA; AMAM005734-PA; AMAM005734.
DR VEuPathDB; VectorBase:AMAM005734; -.
DR OrthoDB; 5406587at2759; -.
DR Proteomes; UP000075901; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF346; OPEN RECTIFIER POTASSIUM CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 45..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..96
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 132..219
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 509..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 92043 MW; 46FC2CFDF5E58A2F CRC64;
MLVKYLSPED VALQRKLIGR LDDYCGSRVT NYTEDEYEPP YVWDFYHSFY FAFIICSTVG
YGNISPHNTF GRIFLIFYAL IGLPVNGFFF AYVGEFWARG FVRLYRRYKA YKLSANARYA
PRRISLIGQI VLYLIPGVIV FIFLPACIFT YFEQWPYDVS VYYSFVTLTT IGFGDYAASF
QPSQEHEFGS LFTVYKIFII FWFFAGIGYI FMILGFIAKG ISHKKIQELE KLVASNLKET
QHRVWNGVTK DISYLRKILN EVYMLKFKPV YEEPSDRLLS LSKSRSSSCP ELSMYRSPEL
CITRRKRANS ESVLVFTEPK SLDAGSLVRR LSDTALNRIN REKTFGVQAL VQPAELLARV
VTALGNITAN QDDNQSFLER ASLNAGVNCF SDSQILASER TWSGWSMSGS DKSAYLTAPP
MRPRAASDIG LPPHATSQDA NEWTWSGGDN NQIQQILTIR QKVKQKDNLL RAALSNNTNF
DSSLTINVPP TGAESKASAV NRGMLRRLNP FRKRSKTPAP NDLESGPPLD SYLAATSKGR
SSMFNLPTSS YLMATSRGRG SILSMPPQDE HLLETTTIGD LLRALERMHT DTVTAGDQRG
SFAEPNDSLG RKRTQQTSCV GQSNLPSLLT LFTPPIEAGS RRGSIKPPLG RTGSSDSAPI
MRRPSFRPSN PPSYSATVSG SPAGGGSPTL SVISPSPKPI RRRFSVRPSN LAYPPGHCPR
PLGSGGSEQL GGPHINSSSQ SLHNLPTTTL QRRLSSRPSP LVTNQSSHLT VPTAMASAAG
IGGSSGGQGQ FRWRPNLMRS DSDQSAAPSG WPAAPSGRNR HSSLSNLFDQ KR
//
