ID   A0A182T8C3_9DIPT        Unreviewed;       977 AA.
AC   A0A182T8C3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=EF-hand domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles maculatus.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles; Anopheles maculatus group.
OX   NCBI_TaxID=74869 {ECO:0000313|EnsemblMetazoa:AMAM021658-PA, ECO:0000313|Proteomes:UP000075901};
RN   [1] {ECO:0000313|Proteomes:UP000075901}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=maculatus3 {ECO:0000313|Proteomes:UP000075901};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles maculatus species B.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMAM021658-PA}
RP   IDENTIFICATION.
RC   STRAIN=maculatus3 {ECO:0000313|EnsemblMetazoa:AMAM021658-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A182T8C3; -.
DR   EnsemblMetazoa; AMAM021658-RA; AMAM021658-PA; AMAM021658.
DR   VEuPathDB; VectorBase:AMAM021658; -.
DR   OrthoDB; 3144451at2759; -.
DR   Proteomes; UP000075901; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR015925; Ryanodine_IP3_receptor.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46399:SF8; RYANODINE RECEPTOR 44F-LIKE PROTEIN; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        492..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        582..604
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        772..794
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        850..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          54..107
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|Pfam:PF13499"
FT   DOMAIN          360..610
FT                   /note="Ryanodine Receptor TM 4-6"
FT                   /evidence="ECO:0000259|Pfam:PF06459"
FT   DOMAIN          709..882
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          383..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   977 AA;  110468 MW;  A51C068BECF18542 CRC64;
     MITMMLSMLE GNVVNGTIGK QMVDTLVESA SNVELILKYF DMFLKLKDLT STPSFMEIDS
     NGDGWIMPKD FREKMEQQKS YTPEEIDFLL ACCETNHDGK IDYIGFVDRF HEPAKEIGFN
     LAVLLTNLSE HMPNEPRLAR FLETAGSVLN YFESFLGRIE IMGSSKRIER VYFEIKEANI
     EQWEKPQIKE SKRAFFYSIV TEGGDKEKLE AFVNFCEDAI FEMTHASGLM ASDDDGGTVR
     RDQAFTYISE EEEERAARDP IKRTIQAVKD GLSYSMYMIS PSNIKHQITV LQSKSFPEII
     VGFFKMIFYA FYYSGFGVSV VIKYLVNILM SLMRGPAQEA EEPMPEVEPS LRALPPLPLE
     EPPGTVQAFG LDISKEENGQ YRMAPHESPA LSPSSSIEET GESSPEDGAA ELTGEGVPPG
     EQMTLVDLLG GEAAKRAAQE RTEAQKAQEA TLASIEAESK KASTETKEPA AVHQIDFSKY
     TKKCVSYLAR NFYNLKYVAL VLAFCINFML LFYKVTTFGD DEEGEGSGES LMGLGSGLGS
     GLGILETGSG GGEGGSGDGE GEEEDPLEKV EVDEDFFYME HVLRVAAILH SLVSLCMLIA
     YYHLKVPLAI FKREKEIARR LEFDGLFIAE QPEDDDIKSH WDKLVISAKT FPVNYWDKFV
     KKKVRQKYSE TYDFDSISNL LGMEKTAFAA QEANEGGGFF HFIANIDWRY QIWKAGVTIT
     DNSFLYSLWY FSFSVMGNFN QFFFAAHLLD VAVGFKTLRT ILQSVTHNGK QLVLTVMLLT
     IIVYIYTVIA FNFFRKFYVQ EDDDGEEGDR KCHDMATCFV FHLYKGVRAG GGIGDEIGDP
     DGDEYEVYRI LFDITFFFFV IVILLAIIQG LIIDAFGELR DQLESVKEDM ESNCFICGIG
     KDYFDKVPHG FDTHVAQEHN LANYMFFLMH LINKPDTEYT GQETYVWNMY QQRCWDFFPV
     GDCFRKQYED ELGGGGS
//