ID   A0A182TDP7_9DIPT        Unreviewed;      1344 AA.
AC   A0A182TDP7;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 2.
DT   13-SEP-2023, entry version 26.
DE   RecName: Full=5-oxoprolinase {ECO:0008006|Google:ProtNLM};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC000462-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC000462-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC000462-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   STRING; 34690.A0A182TDP7; -.
DR   EnsemblMetazoa; AMEC000462-RA; AMEC000462-PA; AMEC000462.
DR   VEuPathDB; VectorBase:AMEC000462; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
FT   DOMAIN          8..216
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          236..545
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          763..1293
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
FT   REGION          1286..1306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1344 AA;  143877 MW;  C7B65BF9100835AC CRC64;
     MEGGKYNFAI DRGGTFTDVL CITPDRTVRT LKLLSVDPAN YPDAPTEGIR RILQQETGRA
     LTVDGLIDTG LIGWVRMGTT VATNALLERA GDPVALVVNR GFRDLLQIGN QARPNIFQLN
     IQKPANLYRE VIEIDARLVP AQEASCQLGE ASASWRRLTG AADSTYLEMV PLDEQDLRSK
     LEEVRAAGIN SLAIVLAHSY ACPEHELCVG RIAQELGFQH VTLSHQAMPM CRLVARGFTA
     CAEAYLTPHV ERYLDGFRSG FRDQLRGADV LFMQSDGGLT RMEHFRGARA ILSGPAGGVV
     GYAVTGMRDA GDDDPAAGPP PPLIGFDMGG TSTDVSRYAG TYEHVIESTT AGVTIQAPQL
     DINTVAAGGG SRLFFRSGLF VVGPESAGAH PGPTCYRKGG PLTVTDANLI LGRLLPEYFP
     AIFGPNENEP LDYEATRAAF EQLRMEINEH LASAGEEAGG GPLSLEQVAM GFVRVANEAM
     CRPIRALTQA RGYDTSRHVL ACFGGAGGQH ACSIARQLGM ARVVMHKYAG ILSAYGMALA
     DVVYETQEPC GLELCPDNRA ALKERLHALS ARCVEQLEAQ GFALADEGSI SLEPYLHLRY
     EGTDCALMCA PDRVVENADH TVYGFGDFGR TFRDRYRSEF GFVLEGRRIL VDDIRVRGCG
     RASLFTEPDI AEATGPIYPE KTTVAYFEEG SGQAPPGRLV TPVYDCAKLR YGHRVDGPAI
     LIDRLSTIVI EPGSRALVTR RGDLTIEIGT GSNARPRVDE RLDAVQLSIF NHRFMSIAEQ
     MGRVLQRTSI STNIKERLDF SCALFGPDGG LVSNAPHIPV HLGAMQETVQ YQLRRRGGTL
     KPGDVLLSNH PQAGGSHLPD LTVITPVFAP GEALPVFFVA SRGHHADIGG ITPGSMPPHS
     TSLAQEGAAF KSFLLVDGGV FQEEAIVARL TRPAPGVAGA AGTRNLSDNL SDLRAQIAAN
     QKGIQLVSEL IDAYGLSVVQ AYMGHMQQNA ELAVRDMLRT IAQEARERTG SAVLEAEQQM
     DDGTPIRLVV RIDERHGSAV CDFTGTGPEV SGNCNAPRAI TLSALIYCLR CMVGHDVPLN
     QGCLAPIEVI IPPGSILDPS DGAAVVGGNV LTSQRVVDTV LAAFGTCAAS QGCMNNVTIG
     DEGWGYYETV AGGSGAGPGW HGTGGVHTHM TNTRITDPEI LELRYPIVLR RFTLREDGSG
     GAGQFRGGEG VHRELLFRKP MTLSVLTERR TLRPYGMAGG MPGKPGLNLL IRAGPRGQPG
     HRAVNIGGKT AVQVGPGDIF SMKTPGGGGY GVPLDDDDGP RPTLSDQQQQ RQLAAAAAIV
     SVGSSKAFME RGSVYEYRMA QESV
//