ID   A0A182TE49_9DIPT        Unreviewed;      1053 AA.
AC   A0A182TE49;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   22-FEB-2023, entry version 31.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC000690-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|EnsemblMetazoa:AMEC000690-PA, ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC000690-PA,
RC   ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC000690-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC000690-PA};
RG   VectorBase;
RL   Submitted (OCT-2016) to UniProtKB.
RN   [3] {ECO:0000313|EnsemblMetazoa:AMEC000690-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC000690-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the exportin family.
CC       {ECO:0000256|ARBA:ARBA00009466}.
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DR   AlphaFoldDB; A0A182TE49; -.
DR   STRING; 34690.A0A182TE49; -.
DR   EnsemblMetazoa; AMEC000690-RA; AMEC000690-PA; AMEC000690.
DR   VEuPathDB; VectorBase:AMEC000690; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR041123; CRM1_repeat.
DR   InterPro; IPR041235; Exp1_repeat_2.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR045065; XPO1/5.
DR   InterPro; IPR014877; XPO1_C_dom.
DR   InterPro; IPR040485; XPO1_repeat_3.
DR   PANTHER; PTHR11223; EXPORTIN 1/5; 1.
DR   PANTHER; PTHR11223:SF2; EXPORTIN-1; 1.
DR   Pfam; PF08767; CRM1_C; 1.
DR   Pfam; PF18777; CRM1_repeat; 1.
DR   Pfam; PF18784; CRM1_repeat_2; 1.
DR   Pfam; PF18787; CRM1_repeat_3; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM01102; CRM1_C; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          44..110
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
SQ   SEQUENCE   1053 AA;  121894 MW;  F24E27B5EDFF32AF CRC64;
     MAIPMIRLDE ANQLLDFSKK LDIDLLDNIV SCLYNSTGEQ LRLAQTVLTT LKEHPDAWTR
     VDSILEFSQN QQTKFYALQI LEEVIKTRWK ILPRNQCEGI KKYVVGLIIK TSQDPAMMEA
     NKVYLNKLNI ILVQILKREW PNNWETFISD IVGASKTNET LCQNNMIILK LLSEEVFDFC
     SGQITQTKAK HLKDTMCSEF AQVFTLCQFV LENSLNAPLI SATLQTLLKF LNWIPLGYIF
     ETKLIDMLVC RFLTIPMFRN ITIMCLSEIA GLQLPNYDHV FIALFKQTME QFDTMIPPNT
     NMNQIYMNGS DDEQCFVQNL AMFLCTFLRV HATLVEKRDT MEVVLKALDY LVMISEVEDV
     EIFKICLEYW NSLTGELYKE AHTSSQRRTF YHKILSKVRY IMISRMAKPE EVLVVENENG
     EVVREFMKDT NSINLYKNMR ETLVYLTHLD YADTERIMTD KLNNQVNGSE FSWKNLNTLC
     WAIGSISGAF FEEDEKRFLV TVIKELLGLC EHKKGKDNKA IIASNIMYVV GQYPRFLRAH
     WKFLKTVVNK LFEFMHETHD GVQDMACDTF IKIALKCRRH FVQLQPNESC TFIEEILATM
     SSIICDLQPQ QVHTFYEAVG YMISAQADQV QQDILIEKYM MLPNQVWDDI ISQATKNVDI
     LKDMGAVKQL GSILKTNVRA CKALGHSYVS QLGRIYLDML NVYKIMSENI TQAISLNGLS
     INNQPLIKAM HVVKKETLTL ISEWVWKSND PKMVMENFIP PLLEAVLFDY QRTKVPNARE
     PLVLSTMASI VNRLQAVITP EIPKIFDALF DCTLDMINKN FEDYPQHRTN FYELLQAVNM
     YCFKAFLSIP PEQFKLVFDS IVWAFKHTMR NVADTGLNIL MQMLQNLEQH PQAAQSFYQT
     YYTDILMQIF SVVTDTSHTA SLQNHATILA YMFSLVEAGR ITVKLGPSDD NVLNIQEYVA
     MLLKSAFSHL TGNQIKIFVT GLFNLDQDVH AFKEHLRDFL IQIKEVTGED DSDLYLEERE
     NELKKIQEEK RRMLMTVPGM MNPHEMPEDM QDE
//