ID A0A182TEJ2_9DIPT Unreviewed; 1117 AA.
AC A0A182TEJ2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC000905-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC000905-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC000905-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine.
CC {ECO:0000256|ARBA:ARBA00037785}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|ARBA:ARBA00006459,
CC ECO:0000256|RuleBase:RU003732}.
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DR AlphaFoldDB; A0A182TEJ2; -.
DR EnsemblMetazoa; AMEC000905-RA; AMEC000905-PA; AMEC000905.
DR VEuPathDB; VectorBase:AMEC000905; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR CDD; cd10324; SLC6sbd; 2.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616:SF241; SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 2.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 2.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 2.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 2.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 42..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 885..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..942
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 954..975
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 995..1017
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1029..1053
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1117 AA; 124377 MW; 9415153AE8867834 CRC64;
MAGASTTTTS ITQLTIDGSV APEVNTREPH EPKEREKWGR GIEFLLSCIA LSVGFGNIWR
FPYTAMQNGG GAFLIPYLIV LLLVGRPLYY LEMVMGQFAS RGCIKVFDVA PLMRGVGVGQ
TLALLLILGY YAAVLSVSVR YFVASFVSPL AWARCEPDWS GCVDSEFKGR VQNASLRPSA
EYYFNRTVLH NFWTVEDGIG VPDWKLAVCL LFCWICITGI LIKGIRSSGK ASYFLAIFPY
VILLVLLVRT CTLEGADQGI LYLMKPQWEK LIDVQVWYAA VTQCFFSLTI SLGSVIVFAS
YNSFTNNIYR DAMIISWLDT FTSIVSGIVV FGIVGNIAHI TGNRVEDMQL QGPQLTFITY
PDAIAKFDAA QNVFAVLFFL MFFLLGLGSN TGIVTTIVTA VRDRFPQLPN WKVVTLIAIY
GFCCGLVYIT PGGLHVLDVV DKYGVTLTTL TLVMLEIVTF CWMYGIEQIG HDIQLMLSRK
TGLDSFAPAD PMENLGYASG QVEPGEKGTQ AADSRSVASP MNSSITLHTI SDDTKTTTST
RDKWGRDIEF MLSCIAYSVG FGNIWKFPYT ALKHGGGAFL LPYLIVLFIV GRPIYYLEMI
LGQFSSRGCV KLYDLAPAMR GIGVAQTIAM FVVMTYYAPV LAITFRYFVA SFSSSLPWSE
CNPDWANCVN SSFVGQLEPT NGTAVGLQSS AELYFLKEVI HKAPSLEDGL GMPDWKLALC
LLFAWTVVAT ILIRGAKSTG KASYFLAIFP YVIIIILLLQ TLMLDGAMQG ILYFITPQWD
KLLSIEVWYE AVTQCFFSLS VCYGGIIAYS SFNNFSNNVH RDAVIISWLD TFTSIVAGCI
VFGVIGNLAY VSGQPDIQKL ARDGAGLTFM TYPDAIAKFQ FLPQLFAALF FLMLFIVGVG
SNLGVTTSII TAIRDQRPQL RHWQVVLGTV TVGYFFGLLY LTPGGFDFLD VIDYYGAKYV
TLTFAVLELA TVAWIYGVDR ICRDIRFMLG IETSFYWRVC WGLIAPAATL LILIFSFADF
ELQKVPMGYN VLGLFIYAIA VLQLPGWYCY AVWRRRSKQT ESLRKAAHNA LKPMDIWGPE
SDTVRLQYQT EEEQYQNSQP LERSTVQRIK KRMFNMG
//
