ID A0A182TIY1_9DIPT Unreviewed; 307 AA.
AC A0A182TIY1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=ER membrane protein complex subunit 2 {ECO:0000256|RuleBase:RU367091};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC003140-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC003140-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC003140-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Part of the endoplasmic reticulum membrane protein complex
CC (EMC) that enables the energy-independent insertion into endoplasmic
CC reticulum membranes of newly synthesized membrane proteins.
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU367091}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU367091}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU367091}.
CC -!- SIMILARITY: Belongs to the EMC2 family. {ECO:0000256|ARBA:ARBA00010361,
CC ECO:0000256|RuleBase:RU367091}.
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DR AlphaFoldDB; A0A182TIY1; -.
DR STRING; 34690.A0A182TIY1; -.
DR EnsemblMetazoa; AMEC003140-RA; AMEC003140-PA; AMEC003140.
DR VEuPathDB; VectorBase:AMEC003140; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0072546; C:EMC complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR039856; EMC2-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR PANTHER; PTHR12760:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR12760; TETRATRICOPEPTIDE REPEAT PROTEIN; 1.
DR Pfam; PF07719; TPR_2; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU367091};
KW Membrane {ECO:0000256|RuleBase:RU367091};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803}.
FT COILED 87..118
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 307 AA; 34873 MW; A8FE513E77B077C9 CRC64;
MSYNVEEMSW SDARNLLRKW RDDNERKSDD VMQLWDNVLS SKQSKLGNER HLVLEQVIIA
ALDCNRIETA EHCVSILSAE FPGSLRIQKY RSMLLEALER YDDALDELEQ IIRKDETNAA
PRKRKVAILK TQGRTAEAIK ELCDYMKIFM SDQEGWHELC NLYLAEGEYA KAAFCMEELL
LHNPHSHLIH QRLADIRYTM GGLDNIEMAK THYCKAVKLN VNNLRALYGL FLCCGHISNS
KLVIGKRKEA QKLAQWAMAQ IQARTQPTAK DTKGAIKTGK SKAAGCEDEL QALEQAFGGL
DVGKVAN
//
