ID   A0A182TJG7_9DIPT        Unreviewed;       633 AA.
AC   A0A182TJG7;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   13-SEP-2023, entry version 21.
DE   RecName: Full=SPX domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC003428-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC003428-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC003428-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC       {ECO:0000256|ARBA:ARBA00009665}.
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DR   AlphaFoldDB; A0A182TJG7; -.
DR   STRING; 34690.A0A182TJG7; -.
DR   EnsemblMetazoa; AMEC003428-RA; AMEC003428-PA; AMEC003428.
DR   VEuPathDB; VectorBase:AMEC003428; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd14477; SPX_XPR1_like; 1.
DR   InterPro; IPR004342; EXS_C.
DR   InterPro; IPR004331; SPX_dom.
DR   PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR   PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR   Pfam; PF03124; EXS; 1.
DR   Pfam; PF03105; SPX; 3.
DR   PROSITE; PS51380; EXS; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        234..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        340..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        499..517
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..176
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
FT   DOMAIN          427..629
FT                   /note="EXS"
FT                   /evidence="ECO:0000259|PROSITE:PS51380"
FT   COILED          70..97
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   633 AA;  74547 MW;  C17135D1A8B70AD8 CRC64;
     MKFAEHLAAH ITPEWRKQYI QYEEMKAQLY AAVEQSPSAE LVDPEVLTRY FAKFDEQFFH
     YCDSELAKIN TFYSEKLAEA TRKFANLRTE LSETLEMEES TKMKKKDNLH KMKKNLLRKK
     NVSVRKIQEL KLAFSEFYLS LILLQNYQNL NFTGFRKILK KHDKLLNVDF GARWRAEHVE
     SAHFYVNKDI DRLIHETENI VTNEIEGGDR QRAMKRLRVP PLGEQQSPWT TFKVGLFSGS
     LIVLCVAVVL SAMFRLRRDD WIVAFRLFRG PLLIVEFMFL WGINVYGWRS SGVNHVLIFE
     LDPRNHLSEQ HIMELASIFG VIWTMSVLGY LYADALAIPA YLSPLILYLL MAGFLLNPTK
     TFRHEARFWT LRILSRIVLA PFFYVNFADF WLADQLNSIV PAFLDLQYFL CFFSTLSNWS
     YAEDPNQCIN NSLWIRPVVA MLPAWFRMAQ CLRRFRDTRD AHPHLANALK YSTSFFVVIF
     SSITQATRDQ YAKSSDNPWF YLWILASIVS SCYAYTWDIK MDWGLFDSKS SDNNPLEVFR
     RFIWNYFRLE NEHLNNCGNF RAVRDISVAP MDCSDQTTIL RMMDEEDGVR NRRTVKKLAN
     KKKSEQRLLL REAESTEDLE ISDNSKRQVQ WEI
//