ID   A0A182TK19_9DIPT        Unreviewed;       658 AA.
AC   A0A182TK19;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC003735-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC003735-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC003735-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation
CC       symporter transporter (TC 2.A.2) family.
CC       {ECO:0000256|ARBA:ARBA00038193}.
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DR   AlphaFoldDB; A0A182TK19; -.
DR   EnsemblMetazoa; AMEC003735-RA; AMEC003735-PA; AMEC003735.
DR   VEuPathDB; VectorBase:AMEC003735; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:UniProt.
DR   CDD; cd17313; MFS_SLC45_SUC; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR19432:SF35; LP09277P-RELATED; 1.
DR   PANTHER; PTHR19432; SUGAR TRANSPORTER; 1.
DR   Pfam; PF07690; MFS_1; 2.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        124..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        157..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        190..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        249..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        289..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        330..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        447..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        497..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        554..576
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        604..623
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        635..656
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          41..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   658 AA;  72013 MW;  69E532C2AE5F3BA8 CRC64;
     MYREIKSIYN WLASAAISVT QTLTDSRRPI IRALQCSRRQ RSFSNSSSSS SRGGTADLTM
     VKTGPGGGPS AASGRVVLAR RKSLAQKDPL MEELRKAREE NARQQQYDYS HVFRKKTLLD
     FVRLSFVIMG IEIVYSAETA FVTPILLGIG IEHQLMTIVW GISPLIGFIV SPFLGTFSDR
     CRSRFGRRRP LLVVLGMGLV LGCLLLPFGE TIGHWLGDTG ESVKPVINNT VTIGGNRNPY
     GSATASTAHY KWAIVVTILG TILLDFCADS SQAPSMAYLL DVSLPDDHGQ ACSTYSLLSG
     VGGCIGYLIG AIDWNGTMLG ELLGGNINTV FILVTVIFVL CLAVTVGSFR EIPLPLMERD
     ELLQPLTERA VTEQRQRTTV EKGLRPMKDI ADALLLELEG DDSEPSDRTA SLSYSEKEPL
     MGDFLQEKPK SSAKEFLRIT FRIPANLAVL CLTNLFCWMS HISYSLYFTD FVGEKVFGGD
     PMAHSDSDEY ALYIEGVRYG CFGMAIYSIA CSTYSCTIER LIRVFRARNV YSGGLLIDFV
     GMLLMGMFPS KVTVYVFSVT GGIVGALLFT MPYIILAKYH AKGLLDTCDE TISMQPRRGL
     ASDISIVGSM LFMAQIILSL TMGPLVTLTG TTASVIYTAS VCSLVASLCA TQIQYLDL
//