ID A0A182TKB2_9DIPT Unreviewed; 3875 AA.
AC A0A182TKB2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Muscle M-line assembly protein unc-89 {ECO:0008006|Google:ProtNLM};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC003870-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC003870-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC003870-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 34690.A0A182TKB2; -.
DR EnsemblMetazoa; AMEC003870-RA; AMEC003870-PA; AMEC003870.
DR VEuPathDB; VectorBase:AMEC003870; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR CDD; cd13325; PH_unc89; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 21.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF8; WRAPPER_REGA-1_KLINGON HOMOLOG; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 20.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 18.
DR SMART; SM00408; IGc2; 15.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 20.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 11.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 44..148
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1533..1639
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1654..1741
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1840..1932
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2030..2121
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2638..2735
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2835..2932
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2940..3030
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3037..3126
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3230..3327
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3333..3421
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3435..3524
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3548..3648
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 292..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1059..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2356..2375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2386..2518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 378..405
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 992..1035
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 292..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..669
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..797
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2386..2405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2406..2504
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3875 AA; 431681 MW; 676096160FC262D0 CRC64;
LLKYSTALGE NVLDIQKALE LMLSVPSRAA NNKFLEAIEG FRGNLQKLGR VLAHEYFGVR
DRENKIKERY LFLFKSRILV TKVKRLSDDR SIFIMKDIVR LPDCELRDID TRAFELVPKG
KGSDPVHLIA YSEEAKQRWI YEISEYANNA VALQEHSNDD LRLDPTQTNI DDSIIKLPQR
IEAHKTDENI KPSDIADSYV VFKHKTSRDE SHQALQKIQY LQQQQQQHLP QQLGESAEPA
VVVVEEEEEK SASVQERLAA FEVKKSAKKL DLTHTKQQEA IAVASSVVQS ETKTASSSSS
SVSVTSSSVS VKEEQHERSV AVKRQQELQQ LESKYTAHIQ QAKELVKESI EATIKSEAEP
KPEPTSADSP QTESLSKIQQ IESKYAALKA RQQQQLQEIK AAEVTTETTV TVAQQQQTQT
PSAEEPQSKI AQIEAKYAFK RQQSLSVDES LNSKLPVPLK KEAEVQSTVK VAKQETTATK
TEQVTKTSEV KAAEIKSAEA VKVQETVKVE QKEVKESKKK IPEPIKLTEQ VTKTVGDKGP
DSPKKGKTPK TPKSPSPKKE AVPFKPKPEE PKKIVEPAKT VPAKPAEPTK PQKSVEASKP
AKPVNDDKPV EQSKPAEAVK TSKPVESPKP VETPKPAEPV KTVKPAEPAK PVEPVKTEKS
SEEPKNLAEP AKTVKPAESP KAAEPVKVEK PAEPAKLVEP VKTTKTSEPT KPSEPVKPAE
PVKVEKTAEP AKPVEPVKTT KTPEPTKPTE PAKPVKPADP VKVEKPSEPT KTAKLAEPAK
PSPPSKIPEP TKPSKPAEPI AKPVEQAKAT PEPPKKVASE PVKVEAPKAT QPAKAPEPVK
APEQTKPTET PKPVQEPAKT AEPTKPLANK PAESPKVAEP AKVEEQPARR PDSPKSAKKA
SSPKKTSPPK EPKKAPEPAV PKPVEKKTES VKVQEQKKTE TTTATVQKAS ESVKQVETVT
TRKGRTTPAA VSDDASPVEG AVEQKSREEA LNRKLEEIYA REKATLAEAK RIRELEEQEI
RRKFEQRSIR EIQQIKETAT EFLQQIAATR NLVQSVLETS TEPRVPQVTK AATSAAASGG
EGNNSQPSSG AGQEGSSDQS AQEAGSGGDQ GAAPNQSEQS AGEQGGSAGN NNGNDGNGDR
EDKKRTPPPL QLPTFFDPPP PPVYQATIEV FIKKERPPPP PPPKITRKLV VNTDELERKT
QAFFDGEINE PDPDFSIAAA HRKLKGIKNI CKKADETVLY AEDTIVKAEQ GEFDSIVIPE
PEEDKRPREP VYEYQYTVED PVTGARVCTA DPNLVLIEKE LRMEDHYGSA HSRYSSSRLS
SRRSHTSEAH EKELAAIETR HVSKMSTTNT KKIRVPTNIR PHFIKPIRGL TVEPGENAKF
TVQVDEMSNM QWLKDNKPLD DRLADRVITK ENDDLTYSLE IQHCREQDSG IYTARAINGT
ENASCTAQLI VETLTPEQRK AMSESNSPVF SVQLKDTEVI EKTYLTFMVK VKGDPAPKVR
FCKDDKEILD TDKRMKINRD RADIGYYELI IPEVHKGDCG VYSCTAWNKF GTTKTEAQLL
VADQLDLFSE LDNLDDKTKF VWKKNGVAFD PEERFKVLMA DDSDSLALVF QHVKPEDAGL
YTCVAATSSG NIQCSAELTV QGQVNQLIQE PSKPHLEVES REALARIGGK ALLEMKVKGY
PKPEIVWRHE GTIIEPGGRY KFLYEDAESV SLVIKDVQPS DAGAYSIVAQ NELGEDSTFI
NLVVKTPPTI TKPHDMAAMV NEQYKMSIEV NAVPAATVRF FRNGKEIRED DRIKFLTAEN
YYIIKFNHTV LEDAGNYSII AMNEISQASE FWEFTINSPP RTTLRLQEET IVNEKEDIEL
VVKAESNPAP IVRWYKDGKE VVADGKRVVI IAEDGRYVLK IHAANRDDTA LYTADIINDY
GTVTEKSQVN VSTKSKVREQ LTALTCKEGE TNVMLEVKAD GYPRPKVQWY IDDVEITESR
NEYKFQEDGL YYQLVLKEVK AEMQGVYKAR FTNELGTDET SAMTTVQCSP KVRKPLVDTD
VDENTTLTLE VEIYAEPVPE VTWFKNGQPI QTDARLTIKR DSQRVENYTL SLTMVRGADS
GDYEVRAVNS MGTATTKGRV VVQKEQADGE PPVVIEEEAL VTETVAIEVE ETVLQVQSQE
EAEQIVEEPA EEEVQPNVVT VEMSEEVTLV QEVVSEVTIA APIAVPEQVP ETIEDVPAPV
QKAPEPISEQ EEAIVASPGE NAEAHRMISE CMKIGQHGET IMVSVCTEES HAAIVTGPEE
SHSIHQMRAT TVIFEEDSGS PIEVMQKIIY PNKPHASALH VEEIDTITFT SPEQKRQYQS
QQSASDAATR TFIEEFESDN DSAGGKGKLS RGVSINSASE DELQLLSRQA SRTESIPATP
TNATLDKSEL EKETISQESC EEPKVEAVKV EDVPDSPRKG NLLESGTYEE RAGKRSIEKK
VSFEDELSPQ QGKTLERQEV IDNEPEQPEP VKEEVVEKRS ASSKALAKEP IVDGTVEEGA
ENAVITEESQ EPARPEASPE ILKTDIADVT TFDSLPLIWT VEADGIPRPE VCWYHNDELV
KSSDRIRITD SGTTYKIENR DVKEADAGEW KAVVKNRIGE KSLPAKLTVI PCKEYRRPKF
MKGLQNISVH KNEPATLSVT LTSDPEPEIT WLQNGNEVKA DDYIVLKTEI KELEYNLKEI
TYTLHIDQAR HYDTGDYTFQ AKNKYDVSES NGRLDVLLKP EIENFRDTTV LPFTQGVFQV
LVKANPKPKV TWTKDGLNLC NNDNCDVIAD IEKEVYTLVI ESCALAEHGT YTLTASNAQG
ETVATANLNV HTEKPKFTKE PDSLTVHDWA DVYNKVVVQG VPRPAIQWLH NGTPLDTQEI
DEESQEPKIK IVTSGDTEVT SELFITHFGP ELQGEYSCLA TSIGGETEAK FNIQVKNEQP
VFGKGLERSL DLEEDDRLEL RCIVDGSPLP KMTWYKDSNE IKADDHVKIT YGHDGICRLV
IDNVLPGDSG CYKLVLSNKS GDVTTQCGVA ITPKQKPPVF VRPLQDHKLT VGDTLHMEAE
IAGFPMPEVR WFKDGLPLRQ IRGINFINQP DGLVGFIIDR VTAEDAGIYT CEVKNKNGEA
KSASLTEIVP KGKKPQFVSE LMNANIVEGF PIKLTVKVIG YPQPAVKFTH NGTLVAGDRY
RITEEGEGAF TLALDKTTGT DCGEYQAIAT NEHGETISAA TVNILPTTDP SLPEEPPSFL
GGLRDITADE GKELTFSARF AGNPAPEVIW TKDGEPLQPT GRVSVTCDGK SVGLTITPAE
MSDSGEYACL MANPLGETET RAAAIVRKVF QKPNFVYPFS DMQQLPGLEA KFPAKLVGVP
RPEVQWYKNE SPIHPDDRYK MKYEGDCVCL YIKECAPEDT GLYSCTATNR EGSSTIEAKL
DVVTRIEKRD EPTPPSFMKK LNDMTLLDGM KGKLTVCVDG FPMPTVEWIR DGRRLVPSEK
YRIEAEKNGL ARLIVDDVQE EDLGRYSCKA VNNLGEAICH ANLKFEPSDY RPRRRYVKGK
GKDLLHTPPY PLTEKPIISK LSDRRLTLSW RPSMTTVPRY PVTYQLEMIE LPDGEWHTTR
SGIRGCSCEV RNLEPFREYK FRIRVENLYG VSDPSPYVQT YRQKLEPEPP VFYPYLGPGR
DFRPDTSAHY PRDFDVERPG HRHQAQAPEF LRQEQPVQYG TKNHNVSLFW FVYGYPKPTM
TYYFNDQIIE AGGRYSFSYT RNGQATLFIN RMTDRDVGVY EAVATNEHGS VRQRVCLELG
EYPRFLQRPE EVFIMGRRSG RVEAKITGVP FPDIKWYKDW QPIHESSRIK VRLRRKRDSC
LVVRAQNRNY TIPIPCSDLI PKPIPIMESI LISSL
//
