ID A0A182TM49_9DIPT Unreviewed; 451 AA.
AC A0A182TM49;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE RecName: Full=CCR4-Not complex component Not N-terminal domain-containing protein {ECO:0000259|Pfam:PF04065};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC004833-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC004833-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC004833-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CNOT2/3/5 family.
CC {ECO:0000256|ARBA:ARBA00007682}.
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DR AlphaFoldDB; A0A182TM49; -.
DR STRING; 34690.A0A182TM49; -.
DR EnsemblMetazoa; AMEC004833-RA; AMEC004833-PA; AMEC004833.
DR VEuPathDB; VectorBase:AMEC004833; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0030015; C:CCR4-NOT core complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR040168; Not2/3/5.
DR InterPro; IPR007207; Not_N.
DR PANTHER; PTHR23326; CCR4 NOT-RELATED; 1.
DR PANTHER; PTHR23326:SF1; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3; 1.
DR Pfam; PF04065; Not3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 4..228
FT /note="CCR4-Not complex component Not N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04065"
FT REGION 239..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 41..68
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 240..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 49404 MW; AEB1A3B63B60F103 CRC64;
MAATRKLQGE IDRCLKKVTE GVETFEDIWQ KVHNATNSNQ KEKYEADLKK EIKKLQRLRD
QIKSWIASGE IKDKSALLEN RRLIETQMER FKVVERETKT KAYSKEGLGA AQKMDPAQRE
KEEISTWLTS SITSLQIQID QFECEVESLL AGKKKKLDKD KQDKMDELKG KLERHKFHVT
KLETLLRMLD NDGVEVEQIK KIKEDVEYYI DSSQEPDFEE NEYIYDDIIG LDDVEISGIP
VSTGTDSNNS NETAGSPSSL ISGTSPAQSP VLNYSASTLH NHSSDLSADN NNLNEKRSKS
EGTKITPPNS IPIIGPAFAA VAKQHPISSS NLLPTSSATA TITNGPNTII NTNSSISNAA
NVNSGGGGGG GGPGGMKPSA GTHEACIPPL LGVAPLGTSK LQKEHQIQVI LMGMILFCGT
LVADEHLFSF ASSNSWKPPT IICQHQAIQR G
//
