ID   A0A182TML1_9DIPT        Unreviewed;       686 AA.
AC   A0A182TML1;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=SF4 helicase domain-containing protein {ECO:0000259|PROSITE:PS51199};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC005072-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC005072-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC005072-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182TML1; -.
DR   STRING; 34690.A0A182TML1; -.
DR   EnsemblMetazoa; AMEC005072-RA; AMEC005072-PA; AMEC005072.
DR   VEuPathDB; VectorBase:AMEC005072; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd01122; Twinkle_C; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR027032; Twinkle-like.
DR   PANTHER; PTHR12873; T7-LIKE MITOCHONDRIAL DNA HELICASE; 1.
DR   PANTHER; PTHR12873:SF0; TWINKLE MTDNA HELICASE; 1.
DR   Pfam; PF13481; AAA_25; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51199; SF4_HELICASE; 1.
PE   4: Predicted;
FT   DOMAIN          408..661
FT                   /note="SF4 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51199"
FT   REGION          654..686
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   686 AA;  77120 MW;  035BD3BCD8BA449D CRC64;
     MLVKRLFCSY AKALNRLQRA PSGSKHTSSD YNDVAPFECR PLVRCFSIDA NHPPDDGQKP
     VTTVSLYHMK KIIKASSTVL GESVEGPTCI QTVCPVCHVV PGGAEGKPIS DAIRSKIFVN
     KTTGNFTCSS CQYLGRWDHI EKFFPPTSRT PKTVQELRKL RDAFLELKGE HVGTVWPIPG
     DAIAVDTVER AREVIKFLSL ENIIPDTLVS VKARWNEHKR ELFIPLVDVE DRAIGYKTLH
     VGSDGEVFER TVPETNASGL IYLRCNPSNP VAKAKDLSQH NAILVLNVLD LLALGSVKLN
     ATAVCLPHDL KALPQQCLPG LERFQRLTLW FNYDTAGWDT ARNYAKKLDE RRCLFVRPTD
     QHPTPYRALL EGTFEPKAIL SKAQPILHQS ITTFRSLRQD VLSDLQNIDK VQGVKWKRYP
     TLNKLLKGHR KGELTVLTGP TGCGKTTFMS DYSLDLAQQG VSTLWGSFEI RNTRLAVTLL
     RQMVGRPLDE NLSEFEQWAD AFERLPIYFM TFHGQQPIKI VMEAIEHAQY VHDIQHVIID
     NLQFMMGVLD EAKHLDRYWK QDAIIAAFRT FATKRNCHVT LVIHPRKERD TDELTTSSIF
     GGAKASQEAD NVLIIQDKRL TSVRGKKYLQ VAKNRYSGDL GIMPLDFDKA SLSYAQRKKK
     PDGEDGGSSE GPAGSEQINR TVGRAF
//