ID   A0A182TN72_9DIPT        Unreviewed;       755 AA.
AC   A0A182TN72;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=FAD-dependent oxidoreductase 2 FAD binding domain-containing protein {ECO:0000259|Pfam:PF00890};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC005368-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC005368-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC005368-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   AlphaFoldDB; A0A182TN72; -.
DR   STRING; 34690.A0A182TN72; -.
DR   EnsemblMetazoa; AMEC005368-RA; AMEC005368-PA; AMEC005368.
DR   VEuPathDB; VectorBase:AMEC005368; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   PRINTS; PR00411; PNDRDTASEI.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        34..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          185..723
FT                   /note="FAD-dependent oxidoreductase 2 FAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF00890"
FT   REGION          104..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..656
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   755 AA;  80011 MW;  2F2F8592070207DB CRC64;
     MNLIIVATSI GFGMIPIAAP TFYHQFPGWF ETIFHSGISS AAIMAIVLNL VFNHFTAGTP
     DQPSVIAAGR ERQLRYTDIA CLNEGDYFQN GKLYDAAGNE VPLCEDDDHH PAPRSAGRSS
     KAAEPSRPSG LPGLLETPVH FRSLTAHCPP RLIGPSPGAS IEYGTSFHIQ EYPMPIPASP
     PLECDLLVIG SGAAGLAAAV TAAHHGKRVV LVEKDPVLGG ATAWSGGWMW VPRNPLARRS
     GIDEAPAQAR TYLRHVLGEH YRAELVDAFL DHGPEMVAFF EQHTALQFAD GNGIPDMHGD
     APGAATGGHQ LIAAPYDGHA VLDLLPRLRT TMRETSFLGM PIMAGTDLAA FLNLTRSPRA
     FLHVARRVSR HLWHLARHGR ALQLVNGVAL VARLARSAED QGVTLLTQAP ARRLLLQAGR
     VSGAVIEQDG VEHSIRARAV LLATGGFAHD AERRRELVPH ERNGQATLAL PPPGCSGDGL
     RLGESAGGVV ARDLRAPLAW APVSEVPHGD GSTGHFPHII ERGKPGVIAV LPSGQRFVNE
     AHGYYDYVDA LLRATPEGEP VVSWLVCDHR FLRRYGLGHV RPAPLPISAH LRSGYLKRGA
     TPEALAAACG IDPAGLAATL AAYNRHARDG QDPAFGRGST AFNRRSGDPG HPGPNPCVAP
     IEHGPFYAVK VLPGCFGSFA GLRTDGHARV LDAQGQPITG LYAAGTDMAS VMGGHYPSGG
     INLGPAMTFG YIAGRHAAGL DAPARSPRAV TEPVG
//