ID   A0A182TR16_9DIPT        Unreviewed;       698 AA.
AC   A0A182TR16;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   08-NOV-2023, entry version 27.
DE   RecName: Full=Nucleolar protein 10 {ECO:0000256|ARBA:ARBA00015517};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC006796-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC006796-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC006796-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the WD repeat NOL10/ENP2 family.
CC       {ECO:0000256|ARBA:ARBA00005264}.
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DR   AlphaFoldDB; A0A182TR16; -.
DR   STRING; 34690.A0A182TR16; -.
DR   EnsemblMetazoa; AMEC006796-RA; AMEC006796-PA; AMEC006796.
DR   VEuPathDB; VectorBase:AMEC006796; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR040382; NOL10/Enp2.
DR   InterPro; IPR012580; NUC153.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR14927:SF0; NUCLEOLAR PROTEIN 10; 1.
DR   PANTHER; PTHR14927; UNCHARACTERIZED; 1.
DR   Pfam; PF08159; NUC153; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   DOMAIN          476..502
FT                   /note="NUC153"
FT                   /evidence="ECO:0000259|Pfam:PF08159"
FT   REGION          512..597
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          646..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        512..526
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        540..564
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        565..597
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   698 AA;  79963 MW;  6D3E4FD20848847D CRC64;
     MLVTDINNVK IYNLSGGKSI PEWLTDRKQK KAPKKNADAD RHIELIQDFD MPGVASCIAI
     SDDGQYILAT GTYKPRVKCF EVSNLSLKFE RCFDSEVEKF TILSEDYSKL AFLHADRYVE
     IHAAAGRHYR LRIPKFGRDL VYHRPTCDLL FVGTSPEIYR LNMERGQFLL PYTSTTASAI
     DSVTINPEHQ LICVGTQEGR LEAWDYRDKR CCGTLDVAAN LPSTNGVAAV TALQFKTGLT
     LAAGTSSGHV LLFDIRARNP IAIKDHLNQL PIKKIRFQPD QKSVYSLDGA MLKIWDETSL
     KQKACIESRS NFNDFAHFPG SGMFMFAQED TKMLPYYIPS EGPAPKWCSF LDNLVEEIAS
     ETVQNVYDDY KFVTKQELAD LKLDHLEGTP MLRAYMHGFF INIRLYNKAK AVSDSFAFDN
     FRKDKIRKQI EESRPARLQI KSALPKVNRE LAQHLIQEEH MSNAKRSAIA KGLLGDDRFK
     QMFDNPDFEI DKEAEDYRLL SAVLKRADRD KARRKEKIVV TEPNEEDEGK STDDDLYSEK
     SESEKEDEEE DEEEEEEEEK DEEMEDAKPA YSKMKNNRPD KSWAHEEADH EDDDKEFSLT
     VEEGANFDIM QPAKKIQSVS LGKRVNKLEH ATTNVQFQNG VGRREITFTT TGRSSSGKNA
     MDRERARYQS ELKKHKEERR QVIRSAKGVI KKTIFKKL
//