ID   A0A182TRI8_9DIPT        Unreviewed;      1392 AA.
AC   A0A182TRI8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Tuberous sclerosis 2 {ECO:0008006|Google:ProtNLM};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC007047-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC007047-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC007047-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   STRING; 34690.A0A182TRI8; -.
DR   EnsemblMetazoa; AMEC007047-RA; AMEC007047-PA; AMEC007047.
DR   VEuPathDB; VectorBase:AMEC007047; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003913; Tuberin.
DR   InterPro; IPR018515; Tuberin-type_domain.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   InterPro; IPR024584; Tuberin_N.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR   Pfam; PF11864; DUF3384; 1.
DR   Pfam; PF03542; Tuberin; 1.
DR   PRINTS; PR01431; TUBERIN.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   4: Predicted;
FT   DOMAIN          49..470
FT                   /note="Tuberin N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11864"
FT   DOMAIN          551..911
FT                   /note="Tuberin-type"
FT                   /evidence="ECO:0000259|Pfam:PF03542"
FT   REGION          660..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1037..1111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1144..1186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1203..1240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1051..1067
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1068..1106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1144..1176
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1203..1224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1392 AA;  154070 MW;  1B6B4FF59FB23115 CRC64;
     MAARERETQL SRIKQFFRMS KPGSVSSSRH DLPISPELER ELRPETPVTQ RCKALRDFGD
     QVLTSRLEPD AVQSLWELTK DLLVGNKLME QRQCALAFYC RLIQGQYDRL GLMRAQFYRV
     IESHSEPEDI SYRLEMLKLL TETGKNIQHF EKEIGAFLLD WIKPIHEAGL IDSLLELIVN
     LIKYNAASLE PKFLVGVVSY IFDMTCNKQE TNTILLCLSV LDCFICYAII PNESLTLFII
     ILCRMVNQEA YCQHSWKIMK NLFGTALGHA TLLTMCNILN NPAFHQDGAL LRGAIFHTNV
     GLWGISVVPI LHCSPSLVLT SFWNALKSRH VIVTYEVILS MNRLIQKSGN ELNEPTWDII
     CDIMTEISHN LAIHRLPADH TVVTHFHETL NMVEQLLQQG TLNADPEKVY GLIEHVSAER
     PEASVRQLID YRASKISATR SEWLKQLCQF MDRFYRMKSS NVRIYAVQAL ERIMTANRAA
     YEDEILERIV IVHLGTVPLE KDPEVRKAVA RTLIEFTIHC ETKRCIELLE IVEKLLQRPY
     EENQVVRSEQ EAEDIILLVD GLIRLFIVKL YRLPSLHAIR VYSMLIGLLE QHYQRPHVLA
     NVVTIRYRIF AWMMKARANG SFHIGYPDPE DGNRVRFSHY LGLEGPYQHQ SLQPQPYLSS
     QSTSQLNLTG AGGSEAGSKA MDRIPATNLT TISIKRGCQV IVLCLKEEKD WEVIQLVLTE
     LPSVMQNKAL IQGNDVDSLA RTLYRMYTDK MQLEKLQVSA NVAPKMSDYM ELILPALSSL
     AMYHQHLDTN TQKNIIDALK QGLISRRPHE CIRMLTILLL EMPEQLMPKM ADLLLELSKM
     TGTKMVALPV LEFLSTLILV PSFRFGNFTM RTYMCVMAMS LPFTNPFRYD HYTVSLAHYV
     VAAWFIKCKL PMRHQLVKFI VQGLESYVHV PFQDGSRSFS QKVYSISPLN DDMYRFHCEL
     ADTCVDFMVR HTFSPCSAIS KRLPSAEFLL SGGQSMTWLV GHDLITITTS GCSGVTFRNG
     LCDRCHQYCQ SAGTAANGPG DQSKLMAPYQ QHQQHHHHQH QQHHHHALLS KSNSSASTAT
     TTTTVGGGQP LSPEPPFSSA SSGKDSGLSG IGLGGGGDGA LSAAGNGLPL TLASASSSNK
     RYTKASLQHS SANESDSTDL TTSSSTSSST AATPYPTAPH SAHGGPMVAA NAAAASNRFF
     RQGSQEGYSS GSLEALSRRG SNPDSADPTI GGPGGMMGPV GGELQLQRTS SLVAPRAPPG
     LMATIGNRLI LPQQLSSSLT GGVGGGSSSS SGIGFDRPVQ PCACVCTGWA EVCVRRPTGF
     TSWITRIQSQ VSHDILGGDV SLQDLTSLFS PSVGGGVIGP DYMTLGTGGH PSYSGDGLTP
     FGSSADIPSA TM
//