ID A0A182TRP5_9DIPT Unreviewed; 2417 AA.
AC A0A182TRP5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Spectrin alpha chain {ECO:0008006|Google:ProtNLM};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC007130-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|EnsemblMetazoa:AMEC007130-PA, ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC007130-PA,
RC ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC007130-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC007130-PA};
RG VectorBase;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EnsemblMetazoa:AMEC007130-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC007130-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR STRING; 34690.A0A182TRP5; -.
DR EnsemblMetazoa; AMEC007130-RA; AMEC007130-PA; AMEC007130.
DR VEuPathDB; VectorBase:AMEC007130; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd11808; SH3_Alpha_Spectrin; 1.
DR CDD; cd00176; SPEC; 13.
DR Gene3D; 1.20.58.60; -; 19.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035825; Alpha_Spectrin_SH3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF422; PH_9 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 20.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 20.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 17.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 970..1029
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2264..2299
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 2307..2342
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 293..320
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 389..458
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 822..892
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1215..1285
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1640..1674
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2417 AA; 278413 MW; F5EA465A67F39867 CRC64;
MEQFTPKEVR ILESAEDIQE RRDQVLNRYS EFKLETRQKR EKLEDSRRFQ YFKRDSDELE
SWINEKLQAA SEESYRDPTN LQAKIQKHQA FEAEVSAHSN AIVVLDNTGQ EMINQGHFAS
ETIQRRLEEL QRLWELLLSR LAEKGMKLQQ ALVLVQFLRH CEEVMFWIKD KEAFVTADEF
GQDLEHVEVL QRKFDEFQKD MASQEYRVTE VNELADKLLF GGHPERETIT RKKEELNEAW
QRLKQLAILR QEKLFGAHEI QRFNRDADET VAWIAEKDVV LSSDDYGRDL ASVQALQRKH
EGVERDLAAL EDKVAALGTE AGRLCSIHAD HSEQIREKQA EIAAYWQSLT AKAKERKQKL
DESYFLHRFL ADFRDLVSWI NGMKAIISAD ELAKDVAGAE ALLERHQEHK GEIDARVDSF
KLTTEAGRQL LEREHYAAAE VQEKLAALEN DKSSLLVLWE DRRILYEQCM DLQLFYRDTE
QADTWMAKQE AFLANEDLGD SLDSVEALIK KHEDFEKSLA AQEEKIKALD VFATKLIDGQ
HYAADDVAQR RAMLLARRSA LQEKSSVRQK LLEDSNALQQ FERDCDETKG WISEKLKFAT
DDSYLDPTNL NGKVQKHTNF EHELTANKSR IEDITATGQE LATKEHYAAD KVNARMQEIV
TLWESLVRAS DKKGCKLQEA SQQQQFNRTV EDIELWLSEV EGQLLSEDYG KDLTSVQNLQ
KKQALLEADV MAHQDRIEGI KVAANKFVES GHFDADNIRA KEAALSKRYA ALAEPMSIRK
QRLLDSLQVQ QLFRDLEDEA AWIREKEPVA ASTNRGRDLI GVQNLIKKHQ AVLAEINNHE
SRCAGVISNG EQMLNEQPTA SEEIKLRLDA LKDQWNSLKE KSNQRKQDLE DSLQAHQYFA
DANEAESWMR EKEPIVSNQD YGKDEDSSEA LLKKHEALVS DLEAFGNTIQ ALQEQAKNCR
QQETPVVDIT GKECVMALYD YTEKSPREVS MKKNDVLTLL NSNNKDWWKV EVNDRQGFVP
AAYIKKIDPG LSASQQNLID GHSIAKRQTQ INSQYDNLLA LARERQNKLN ETVKAYVLVR
EAADLAAWIK DKESHAQIKD VGEDLEEVEV LQKKFDDFND DLKANEVRLA KLNEIAIQLT
SLGQTEAALK IKTQIQTLNE EWATLQTITQ ERASQLGSAH EVQRFHRDVD ETKDWIAEKE
NALNNDELGK DLRGVQTLQR KHEGLERDLA ALQDKIRQLD ETANRLMQSH PDTAEQTYAK
QKEINEEWQQ VVTKAQQRKE KLLDSYDLQR FLSDYRDLSA WISSMMGLVT SEELANDVTG
AEALIERHQE HRTEVDARAG TFSAFEQFGN ELLQANHYAA PEIQEKIENL NKAREELERA
WTARRLQLDQ NLDLQLYLRD CEQAENWMSA REAFLNAEEV DSKGDNVEAL IKKHEDFDKA
INGHEEKIGA LQVLADQLIA QEHYAGRLID AKRQEVLDRW RHLKEDLIEK RSRLGDEQTL
QQFSRDADEI ENWIAEKLQL ATEESYKDPA NIQSKHQKHQ AFEAELAANA DRISSVLAMG
SNLIDRNQCS GSEEAVQKRL TQIADQWEYL TQKTTEKSLK LKEANKQRTY IAAVKDLDFW
LGEVESLLTS EDAGKDLASV QNLMKKHQLV EADIHAHEDR IKDMNSQADS LVESGQFDSA
GIQEKRQSIN ERYERIRNLA AHRQARLNEA NTLHQFFRDI ADEESWIKEK KLLVGSDDYG
RDLTGVQNLK KKHKRLEAEL ASHEPAIQAV QEAGEKLMDV SNLGVPEIEQ RLKALNQAWT
ELKGLAATRG QKLDESLIYQ QFLAKVEEEE AWITEKQQLL SVEDYGDSMA AVQGLMKKHD
AFETDFAVHR DRCSDIRDHG QTLVTNNNHH GDSISQRCVQ LDKKLENLQA LATRRKTALM
DNFAYLQFMW KADVVESWIA DKENHVKSEE FGRDLSTVQT LLTKQETFDA GLSAFEHEGI
HNITALKDQL INANHAQSAA ILKRHEDVLT RWQKLRADSE ARKYRLLNMQ DQFRQIEDLY
LTFAKKASAF NSWFENAEED LTDPVRCNSI EEIKALREAH AAFQASLSSA QVDFQALAAL
DQKIKSFNVG PNPYTWFTME ALEDTWRNLQ KIIEERDAEL AKEVHRQEEN DKLRKEFAKH
ANLFHQWLTE TRTSLMDGSG SLEEQFEALC HKANEIRARR GDLKKIEELG ATLEEHLILD
NRYTEHSTVG LAQQWDQLDQ LAMRMQHNLK QQIQARNQSG VSEDSLKEFS MMFKHFDKDK
SGKLNHQEFK SCLRALGYDL PMVEEGQPDP EFEEILNVVD PNRDGQVSLQ EYIAFMISKE
TENVQSFEEI ENAFRAITAS DPRPRPYVTK EELYSNLTKD MADYCVQRMK PYNDPKTGHP
ITGALDYVEF TRTLFQN
//
