ID A0A182TRS7_9DIPT Unreviewed; 546 AA.
AC A0A182TRS7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Protein wntless {ECO:0000256|ARBA:ARBA00015887};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC007171-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|EnsemblMetazoa:AMEC007171-PA, ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC007171-PA,
RC ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC007171-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC007171-PA};
RG VectorBase;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EnsemblMetazoa:AMEC007171-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC007171-PA};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- FUNCTION: A segment polarity gene required for wingless (wg)-dependent
CC patterning processes, acting in both wg-sending cells and wg-target
CC cells. In non-neuronal cells wls directs wg secretion. The wls traffic
CC loop encompasses the Golgi, the cell surface, an endocytic compartment
CC and a retrograde route leading back to the Golgi, and involves
CC clathrin-mediated endocytosis and the retromer complex (a conserved
CC protein complex consisting of Vps35 and Vps26). In neuronal cells (the
CC larval motorneuron NMJ), the wg signal moves across the synapse via the
CC release of wls-containing exosome-like vesicles. Postsynaptic wls is
CC required for the trafficking of fz2 through the fz2-interacting protein
CC Grip. {ECO:0000256|ARBA:ARBA00025339}.
CC -!- SUBUNIT: Interacts with wg; in the Golgi. Interacts with Vps35, a
CC component of the retromer complex; wls stability is regulated by Vps35.
CC {ECO:0000256|ARBA:ARBA00025880}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Presynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034107}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034107}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the wntless family.
CC {ECO:0000256|ARBA:ARBA00008148}.
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DR AlphaFoldDB; A0A182TRS7; -.
DR STRING; 34690.A0A182TRS7; -.
DR EnsemblMetazoa; AMEC007171-RA; AMEC007171-PA; AMEC007171.
DR VEuPathDB; VectorBase:AMEC007171; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR047843; WLS-like_TM.
DR InterPro; IPR009551; Wntless.
DR PANTHER; PTHR13449; INTEGRAL MEMBRANE PROTEIN GPR177; 1.
DR PANTHER; PTHR13449:SF2; PROTEIN WNTLESS HOMOLOG; 1.
DR Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Synapse {ECO:0000256|ARBA:ARBA00023257};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 181..502
FT /note="Wntless-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF06664"
FT REGION 522..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 546 AA; 62537 MW; 4F66F021DF5EABF3 CRC64;
MSGTILENLS GKKLSILVAS LLFLQFLCFL LGGLIAPVPA SVQTILATIC KDVPGSHNDT
SVWLYSRGDD RCQSLDHFDI ESDDMKMANQ IVFVFQMPLP REGRQLDYSR WQQNLIGVLQ
TDIAFDANVL HKPHTKMTID ARLAYRNKGD ADQDWKYLAS SLEERDLDCS ANNVTDDYLY
NCNTIPLFEL GSLHHDYYLL NVRLPVDSER RMNLDIGHIK DLHLSVIYQN GGFTKVWVSL
KTVFLPFIVL IMAWFWQRVH LLQRKPALLE EMLLALGCAL TFLNMPFEYF TLFFDMPFML
LLSDIRQGVF YATLLSFWLI FAGEHMLIQE TGEKSSLKTY WKHLSAVAVG CVSLFLFDMC
ERGVQLRNPF YSIWVSKVGA NVALGFIILA GISAGLYFFF LCYMIWKVFC NINIKRTSLP
SMSSARRLHY EGIIYRFQFL MLATLLCAAM TVIGFIIGQV SEGRWKWDDN IDLEFTSAFF
TGVYGMWNIY IFALIVLYAP SHKKWPTNET TENIMSEEIE FSNLPSDSNP SEISSLTQFA
RKAAQD
//
