ID A0A182TT01_9DIPT Unreviewed; 496 AA.
AC A0A182TT01;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=PCI domain-containing protein {ECO:0000259|PROSITE:PS50250};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC007777-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|EnsemblMetazoa:AMEC007777-PA, ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC007777-PA,
RC ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC007777-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC007777-PA};
RG VectorBase;
RL Submitted (OCT-2016) to UniProtKB.
RN [3] {ECO:0000313|EnsemblMetazoa:AMEC007777-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC007777-PA};
RG EnsemblMetazoa;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the proteasome subunit S3 family.
CC {ECO:0000256|ARBA:ARBA00007912}.
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DR AlphaFoldDB; A0A182TT01; -.
DR SMR; A0A182TT01; -.
DR STRING; 34690.A0A182TT01; -.
DR EnsemblMetazoa; AMEC007777-RA; AMEC007777-PA; AMEC007777.
DR VEuPathDB; VectorBase:AMEC007777; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:InterPro.
DR Gene3D; 1.25.40.570; -; 1.
DR InterPro; IPR013586; 26S_Psome_reg_C.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10758:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3; 1.
DR PANTHER; PTHR10758; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3; 1.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF08375; Rpn3_C; 1.
DR SMART; SM00753; PAM; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
FT DOMAIN 249..428
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT REGION 458..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 56276 MW; E15D5F90C69B98E4 CRC64;
MVSQTAAAAA PADPIVDVEM ESAEDAEAAK KDAELLAVQE IRDHARQIDK AVVSKEPRFI
LRVLRSLPTT RRKLALVVVR SLAVQLYPAG PERDGIMAYI EDYPAGAQEP ELPRPRAAIK
SPVPEVDAYF HLLLLVRLLD KNDLPKATKC SQDLMAKVVG QNRRSLDLIA AKSYFYHSRV
AELNNDLESI RSFLHSRLRT ATLRNDFEGQ AVLINCLLRN YLHYSLYDQA DKLVNKSVFP
ETASNNECAR FLYYLGRIKA AKLEYSVAHK QLVQALRKAP QQAAVGFRQT VQKLVIVVEL
LLGDIPERKV FRQAALRRSL GPYFQLTQAV RMGNLQRFGE VLVNFGEQFR QDHTFTLIIR
LRHNVIKTAI RSIGLAYSRI SPQDIARKLG LDSPEDAEFI VAKAIRDGVI EATLDPEKGY
MRSKESTDIY STREPQLAFH QRISFCLDLH NQSVKAMRYP PKSYGKELES AEERREREQQ
DLELAKEMAE EDDDGF
//
