ID   A0A182TU72_9DIPT        Unreviewed;      1314 AA.
AC   A0A182TU72;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Raptor N-terminal CASPase-like domain-containing protein {ECO:0000259|SMART:SM01302};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC008387-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC008387-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC008387-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the WD repeat RAPTOR family.
CC       {ECO:0000256|ARBA:ARBA00009257}.
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DR   STRING; 34690.A0A182TU72; -.
DR   EnsemblMetazoa; AMEC008387-RA; AMEC008387-PA; AMEC008387.
DR   VEuPathDB; VectorBase:AMEC008387; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR004083; Raptor.
DR   InterPro; IPR029347; Raptor_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR12848; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR   PANTHER; PTHR12848:SF16; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF14538; Raptor_N; 1.
DR   PRINTS; PR01547; YEAST176DUF.
DR   SMART; SM01302; Raptor_N; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   3: Inferred from homology;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   DOMAIN          50..203
FT                   /note="Raptor N-terminal CASPase-like"
FT                   /evidence="ECO:0000259|SMART:SM01302"
FT   REGION          217..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          846..876
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1006..1035
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..248
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        860..876
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1006..1026
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1314 AA;  146103 MW;  16E2AD67ADBE55AF CRC64;
     MIETTEQSKD SNDAEDEDDA LLPVCFNCER HRGKILGINC TTQCWRVRDR MKTVSVALVL
     CLNIGVDPPD VVKIDKCARV ECWINPASYS PGKALEMISY QLQKQYERWQ PRARYRHSLD
     PTMEDVKKLC TSLRRNAKEE RVLFHYNGHG VPRPTANGEI WVFNRNFTQY IPLSIYDLQT
     WMGAPSIYVY DCSNAGIIVN SFHTFADQHE LEVEHIRNRS GSTVGHTGGD LQTEDSRSSP
     SPSTGGAGTT TYRNCIQLAA CAADQLLPMN PNLPADLFTS CLTTPVKMAL RWFTLQSTSK
     LVPEVTEELI EKIPGQLNDR RTMMGELNWI FTAITDTIAW NTLRPELFQK LFRQDLLVAS
     LFRNFLLAER ILRAYDCTPI SSPALPPSYR HPMWSAWDLA LDQALAQLPD VLEKGKPFQH
     SPFFEEQLTA FQVWLEGSTE QRSPPEQLPI VLQVLLSQVH RLRALELLGH FVDLGPWAVN
     LALSVGIFPY VLKLLQSSAK ELRPCLVFIW AKIVAVDGTC QIDLIREQGH KYFLIALQDT
     NPGGQPFKGN HRTYAAFVLA SIVHNFPNGQ SSALQGQLVS ICLDQLNDDS NPLLRQWLAI
     CLGHLWQNYE QARWSGVRDN ANEKLYPLLS DPYPEVRAAA VYALGTFISS VKQRSDHANN
     IDRSTAMHLF STVSNDMSPL VRMELIAALQ WMVLFFESQF AGTFLQLDSP ERTTNPMKRV
     LSTSNIIGVG KASVMVGFYQ KLWNGFIALS KDPFPEVASM AQKVVDYVRA DSAKEVTVCD
     KSSHHYGSAA SVSLPPSPNT RVGYLAGESP PTHGGIHGPS DNGGSHHRLA NQQTPLAMKK
     RIHAVNDSPA AGPDYTDSPD KLAYSQSSSH SLSSSTAPLK PIVGTQYIEW SVSFFAQPSK
     RMNEAKAVGT DHNSYEFLIR KSRWLRNKEV RVEGRTQRMK AIFKRLDVQS WSCRTQHAPT
     FIKLNPYDEQ VAFAYNSNLS SSSTSSGYHS LQHHGSHRLI NQSFLEQHHP PPSQSQQPSL
     SPFPHQLKPS NEPLPAHGFG SHALAVTSLE FLNAHDVGVI MAGYSDSTIR LWRPKETSDE
     NQLLSAWHGL LDFNTSSAAK VSCSEAAPAT HGGLVLAWHQ RTQTIMAAGE AKYIRLWDAE
     REMRICDIPS GSDTAVLKLS CAPNGIFAAG FYDGSVRIFD RRCPPAETRC ATIREHINPV
     LAICLRDDCE SLVTADVSAS VRLYDIRKAY SSVQNWSAGT DVSAMAIHTS ADILACATSQ
     IVIYGLDGVV LSSGRSNEGF MAPRKGVASC LSFHKYKLNL AAGYNDNTAA VLVP
//