ID   A0A182TZI3_9DIPT        Unreviewed;       624 AA.
AC   A0A182TZI3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=Cdc23 domain-containing protein {ECO:0000259|Pfam:PF04049};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC011175-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC011175-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC011175-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182TZI3; -.
DR   STRING; 34690.A0A182TZI3; -.
DR   EnsemblMetazoa; AMEC011175-RA; AMEC011175-PA; AMEC011175.
DR   VEuPathDB; VectorBase:AMEC011175; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR007192; APC8.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12558; CELL DIVISION CYCLE 16,23,27; 1.
DR   PANTHER; PTHR12558:SF10; CELL DIVISION CYCLE PROTEIN 23 HOMOLOG; 1.
DR   Pfam; PF04049; ANAPC8; 1.
DR   Pfam; PF13414; TPR_11; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   Pfam; PF13181; TPR_8; 2.
DR   SMART; SM00028; TPR; 7.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 3.
PE   4: Predicted;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          11..235
FT                   /note="Cdc23"
FT                   /evidence="ECO:0000259|Pfam:PF04049"
FT   REPEAT          310..343
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          344..377
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          412..445
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          539..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        576..590
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..624
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  71553 MW;  036F9B1013625446 CRC64;
     MDPPVDLKVV KQDILAGIVE CEKRCLLQCT KWLAELNHGL ADTPLELRGN SAFENVHSGI
     EASEYDSYLL AKSYFLVREY DRSAYFTRNC LSPVPKFLHL YATYMSKEKK RLDNMTDSSV
     VSSVSHAKDF AELLSILRTE HSKDSLDGYC LYLYGVILKK LDLNDIAVRV FVEAINAEPT
     LWSAWLELAP LVNDKRMLEG LKLPNHWMKS IFEGYTYIEL FQNDEGIKIF ENLQKNGFGK
     CIFIPTLLAI AYSNKRDVDR SIDIFQHLQS VDPYRLDNLD SYSNLLFVKD MKTEMSHLAH
     KVVEINKYSP ETCCVVGNYY SIRSDHYKAV MYFQRALKLN PRYLSAWTLM GHEFMEMKNT
     NAAIQSYRQA VEVNKRDFRA WYGLGQAYEI LKMTFYSLYY YKAAQQLRPY DSRMLVALGE
     TYEKLNKVAD ALKCYQKAYN VGDIEGVALY SMAKLYEKQG ETEKAIPAFL KFCSDEKLIA
     DKASLCHAYM TLGNYYEKIE DLDKASYFAY KCLDYEEMKR EAESLLKSIA NKRAHKATTS
     AAAAAANPSG AGKSTEEEKP TPEDVPAETY GEDMEMDETN LSKRIEVAMA EEEEEQEEEA
     GTSELAESSD MPEFHMEDSY DVNE
//