ID   A0A182U0K6_9DIPT        Unreviewed;       995 AA.
AC   A0A182U0K6;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Importin-13 {ECO:0000256|ARBA:ARBA00016020};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC011723-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC011723-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC011723-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBUNIT: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
CC       {ECO:0000256|ARBA:ARBA00011422}.
CC   -!- SIMILARITY: Belongs to the importin beta family.
CC       {ECO:0000256|ARBA:ARBA00007991}.
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DR   AlphaFoldDB; A0A182U0K6; -.
DR   STRING; 34690.A0A182U0K6; -.
DR   EnsemblMetazoa; AMEC011723-RA; AMEC011723-PA; AMEC011723.
DR   VEuPathDB; VectorBase:AMEC011723; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:UniProt.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040709; Importin_rep_1.
DR   InterPro; IPR040520; Importin_rep_3.
DR   PANTHER; PTHR12363:SF56; IMPORTIN-13; 1.
DR   PANTHER; PTHR12363; TRANSPORTIN 3 AND IMPORTIN 13; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF18773; Importin_rep; 1.
DR   Pfam; PF18806; Importin_rep_3; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          25..91
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
SQ   SEQUENCE   995 AA;  112985 MW;  AAF8FF4321D78793 CRC64;
     MDEVQTIEAA VLSFYRGGSE QQKETHKWLQ QVQNSPQAWS FCWELMQLNK SSEIQFFGAI
     TLNSKLRSDW AEVPKEAHHE LKQKLLETIV LFGNGPKIVL NRLCISLGLF IVHMLRHPTV
     IEEVTNMFLH EQLGNLSKVT QIEILMAVLE GIPEEVKNIR TQIPRTVVCE ELNRNAEFVM
     QTVVTYLNEK LSRSAVEPHD MNGLINAAKC TGTWVAHGNV HLNDREGMIQ TLLKAIHYCY
     WKEPKDDGCL MPEENELAET ALKSLANIIS SYATQNAKYS FTVINYMKLF LDVLVPILDA
     EYKENNDNEN LALMIYALFI STLECFSSAI FAGIVTDSEE VSKVYTRTVD MLIKCTDKPG
     TYPVDESCST YAMEFWYMLQ EEVLSMDSGE RKKRCLEAIK PVYAHVVKVL VRKSQLPTES
     SLHKWNDDDL EAFRCYRQDI GDTLLSCHDV LNDLMLDVLS EALDESIMYL SYDPQSTESW
     TLLEATIHAF CSIAQKIEYT EHQQIVKLLK VLNEIPYEKY SDKLFGMALE TVGAYSEWIG
     DNPKYLPSAI TLLVKGLNST KASQATLGLK DLTSECQKEV IPYALPLLDA CRTALQEGHL
     KNAEMIRLMY TVGNILSVIS YENIILYLDA MVSPCFEELQ VHVQNNDRTE PTKARVVLRL
     EMISKLFSSL NIRKPTEGDM DKGLVVGVGP HKLPFPAGGT PAPGAPVQPI LLILEKTMGL
     LKSLCTLWIH NETVIDTLCK ALQQALTNLM DDIKPLLTEM CCLVLSILNT NCVVSAADIA
     GNFILMFYKD QDCRQLMVQL FTAIMDYNFT QMELNVGKLS RIADLIETFY AFNTRISKKI
     PICYSEVQID CMKLVDYATK CMMLPETGPM KKSVAFITMF AKESTNHPVM MNVILAQGEN
     IVRSTFLCIG GTALRTQVEI FADIFLALNF RYPAEFIQWM KLLEVPNFPT AYVSATDKEQ
     FMRKIIKERV NKRLVQDHVR KFAALCRNIV EYENK
//