ID   A0A182U1Q7_9DIPT        Unreviewed;      1223 AA.
AC   A0A182U1Q7;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Helicase SKI2W {ECO:0008006|Google:ProtNLM};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC012304-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC012304-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC012304-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182U1Q7; -.
DR   STRING; 34690.A0A182U1Q7; -.
DR   EnsemblMetazoa; AMEC012304-RA; AMEC012304-PA; AMEC012304.
DR   VEuPathDB; VectorBase:AMEC012304; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   Gene3D; 1.10.3380.30; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR025696; MTR4_beta-barrel.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016438; SKI2-like.
DR   InterPro; IPR012961; Ski2/MTR4_C.
DR   InterPro; IPR040801; Ski2_N.
DR   PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR   PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF13234; MTR4_beta-barrel; 1.
DR   Pfam; PF17911; Ski2_N; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          288..444
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          521..717
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          149..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1094..1121
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1223 AA;  137428 MW;  8D262F42330AFE7D CRC64;
     MSFDPTWLKE PPPIVEDTED LLRAFILEPK IPIHEPKPYF EPRHPSFDQL YDIPHAPIST
     RIVPDRCPET GKVLDFIETQ VQNAGSTAKN SMSLQREPTE SIDSARGSAS YFPFWPGGFD
     EPESVLAGLV PSPLFEKDLK SCPPGFATGV EFETPPTGTD GARATEDSGK SGMVDLLSAI
     ASEEAFVELL PEGLQTRLST NDQSTQGTQQ EPLPAGIDEE EGLLAVTGEM GAGEQVLKIS
     TVTNNALQSA EWAEMLDISK PVDDFYVKIP TMAHRFPFEL DIFQKQAILK LEEHSHVFVA
     AHTSAGKTVV ADYAIALSKK HMTKTIYTSP IKALSNQKYR DFKTTFQDVG LITGDIQIDP
     TASCLIMTTE ILRSMLYCGS DITRDLEYVI FDEVHYITDS DRGHVWEEVL ILLPDHVCIV
     MLSATVPNTI EFANWVGKTK KKRVWVVSTA KRPVPLEHYL YTGFGGKSKD DSFLIVNAQS
     QFVQDGYRRA KESYEAKQAK STGRRTNGPY SQRQEQTLWV GLIDHLQKKE KLPVVAFTLS
     RNRCDNNAEA LMSCDLTTAR EKYAITSFFQ QCLQRLVPAD RVLPQVQQIQ SCLERGIGIH
     HSGILPILKE IVEMLFARGL VKILFATETF AMGVNMPART VIFDSTRKFD GQAFRPLQPS
     EYTQMAGRAG RRGLDKTGTV IILCKQNLPL DGELKTMILG KPVRLESQFR LTYAMMLYLL
     RVELVSVENM MLHSFREFDK RQQMPQSKLE LNQVQEKMSA LSKLSDHLQP LCEFYEAASE
     YLNLRNELLP KQLCQPKAIN ELKVGRVVVV TDEHHYNKLG ILLAVSVQSH KELKLVVLVL
     DHCASGKTQP ASPETLNRGP LWHQMLSLAL PYQTFLPEGV GGHAVLTLAP VNLIELTKHT
     IKCDANGIIR SWEYRLIPRF RDAPPSQSTI EAVAALAELN ATVVQAGSVT GTLELVRFPR
     DLTNLELTQQ LQAAQGRLNR WLPYTGMADF EHEFAVVYDR KQLERKLDEL KYQASYESLS
     LYPDYCRKLQ VLQELKYIDD MQQVAMKGRV ACEMGQNELM ITELVMRNIL TDLQPAEIAA
     LLSSLVFQAK SDVTPKLTET LQKAEAQFRE VENDIRLVER QYGVTDVCKK EELNFGLTEV
     VYEWARNKPF AEIMLLTDIK EGIIVRCIQQ LNETLCNVKD AARIIGDPVL HSKMEEASNA
     IKRDIVFAAS LYTSSTPIVI GEV
//