ID   A0A182U205_9DIPT        Unreviewed;       946 AA.
AC   A0A182U205;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   22-FEB-2023, entry version 23.
DE   RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
OS   Anopheles melas.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC012449-PA, ECO:0000313|Proteomes:UP000075902};
RN   [1] {ECO:0000313|Proteomes:UP000075902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AMEC012449-PA}
RP   IDENTIFICATION.
RC   STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC012449-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A182U205; -.
DR   STRING; 34690.A0A182U205; -.
DR   EnsemblMetazoa; AMEC012449-RA; AMEC012449-PA; AMEC012449.
DR   VEuPathDB; VectorBase:AMEC012449; -.
DR   Proteomes; UP000075902; Unassembled WGS sequence.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 2.60.40.1150; -; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR   InterPro; IPR026739; AP_beta.
DR   InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015151; B-adaptin_app_sub_C.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR   InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR   InterPro; IPR013037; Clathrin_b-adaptin_app_Ig-like.
DR   InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR   PANTHER; PTHR11134:SF3; AP COMPLEX SUBUNIT BETA; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF02883; Alpha_adaptinC2; 1.
DR   Pfam; PF09066; B2-adapt-app_C; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SMART; SM00809; Alpha_adaptinC2; 1.
DR   SMART; SM01020; B2-adapt-app_C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR   SUPFAM; SSF55711; Subdomain of clathrin and coatomer appendage domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002291};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR002291};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR002291}.
FT   DOMAIN          716..825
FT                   /note="Clathrin adaptor alpha/beta/gamma-adaptin appendage
FT                   Ig-like subdomain"
FT                   /evidence="ECO:0000259|SMART:SM00809"
FT   DOMAIN          834..944
FT                   /note="Beta-adaptin appendage C-terminal subdomain"
FT                   /evidence="ECO:0000259|SMART:SM01020"
SQ   SEQUENCE   946 AA;  103479 MW;  00116FAFD37916D5 CRC64;
     MIPIAPIQLR IFDSPKMTDS KYFTTTKKGE IFELKSELNN DKKEKKKEAV KKVVIASMTV
     GKDVSALFPD VVNCMQTDNL ELKKLVYLYL MNYAKSQPDM AIMAVNTFVK DCEDTNPLIR
     ALAVRTMGCI RVDKITEYLC EPLRKCLKDE DPYVRKTAAV CVAKLYDISS SMVEDQGFLD
     QLKDLLSDSN PMVVANAVAA LSEINEASAS GQPLVEMNSV TINKLLTALN ECTEWGQVFI
     LDSLANYTPK DEREAQSICE RITPRLAHAN AAVVLSAIKV LMKLLEILAG DNDFCSMLTK
     KLAPPLVTLL SSEPEVQYVA LRNINLIVQK RPDILKHEMK VFFVKYNDPI YVKLEKLDIM
     IRLANQSNIA QVLSELKEYA TEVDVDFVRK AVRAIGRCAI KVEPSAERCV STLLDLIQTK
     VNYVVQEAIV VIKDIFRKYP NKYESIISTL CENLDTLDEP EARASMVWII GEYAERIDNA
     DELLDGFLEG FQDENAQVQL QLLTAVVKLF LKRPADTQEL VQHILSLATQ DSDNPDLRDR
     GFIYWRLLST DPAAAKEVVL ADKPLISEET DLLEPTLLDE LICHISSLAS VYHKPPTAFV
     EGRGAGVRKS LPNRSASAAG EDSSSVQEAT VIPNQESLIG DLLSMDIGAP AAPAAPAPAS
     SNVDLLGGGL DILLGGGPVA SNDAAPAAPA PAGGSAAGGL LGDIFGIGPV SSSNMIQIPK
     ITWLPADKGK GLEIQGTFSR RAGQVYMDMT FTNKAMQAMT GFAIQLNKNS FGLVPSAPLQ
     VAPLQPSQSV DTSLALGTTG PVQRMEPLNN LQVAIKNNVD IFYFACLVHG NVLFVEDGQL
     DKRVFLTTWK EIPAANEIQY NLHGIVGTAD TVAAKMTANS IFTIAKRNVE GQDMLYQSLK
     LTNNIWVLLE LKLSPGSSDA TLSLKTRSVE VGAIIFAAYE QIIRSP
//