ID A0A182U2D8_9DIPT Unreviewed; 556 AA.
AC A0A182U2D8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Type II secretion system core protein G {ECO:0000256|ARBA:ARBA00020042};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC012646-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC012646-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC012646-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004377}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004377}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the GSP G family.
CC {ECO:0000256|ARBA:ARBA00009984}.
CC -!- SIMILARITY: Belongs to the GSP K family.
CC {ECO:0000256|ARBA:ARBA00007246}.
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DR AlphaFoldDB; A0A182U2D8; -.
DR STRING; 34690.A0A182U2D8; -.
DR EnsemblMetazoa; AMEC012646-RA; AMEC012646-PA; AMEC012646.
DR VEuPathDB; VectorBase:AMEC012646; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.30.420.380; -; 1.
DR Gene3D; 3.30.700.10; Glycoprotein, Type 4 Pilin; 1.
DR Gene3D; 3.30.1300.30; GSPII I/J protein-like; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000983; Bac_GSPG_pilin.
DR InterPro; IPR005628; GspK.
DR InterPro; IPR038072; GspK_central_sf.
DR InterPro; IPR012902; N_methyl_site.
DR InterPro; IPR045584; Pilin-like.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR013545; T2SS_protein-GspG_C.
DR InterPro; IPR049031; T2SSK_SAM-like_1st.
DR InterPro; IPR049179; T2SSK_SAM-like_2nd.
DR InterPro; IPR010054; Type2_sec_GspG.
DR NCBIfam; TIGR02532; IV_pilin_GFxxxE; 1.
DR NCBIfam; NF037980; T2SS_GspK; 1.
DR NCBIfam; TIGR01710; typeII_sec_gspG; 1.
DR PANTHER; PTHR38831; TYPE II SECRETION SYSTEM PROTEIN K; 1.
DR PANTHER; PTHR38831:SF1; TYPE II SECRETION SYSTEM PROTEIN K-RELATED; 1.
DR Pfam; PF07963; N_methyl; 1.
DR Pfam; PF08334; T2SSG; 1.
DR Pfam; PF03934; T2SSK; 1.
DR Pfam; PF21687; T2SSK_1st; 1.
DR PRINTS; PR00813; BCTERIALGSPG.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR SUPFAM; SSF158544; GspK insert domain-like; 1.
DR SUPFAM; SSF54523; Pili subunits; 2.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS00409; PROKAR_NTER_METHYL; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..107
FT /note="Type II secretion system protein GspG C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08334"
FT DOMAIN 221..303
FT /note="T2SS protein K first SAM-like"
FT /evidence="ECO:0000259|Pfam:PF21687"
FT DOMAIN 308..364
FT /note="T2SS protein K second SAM-like"
FT /evidence="ECO:0000259|Pfam:PF03934"
SQ SEQUENCE 556 AA; 60084 MW; 4EBED5026A970B6A CRC64;
MDGVRLASQR GFTLIEIMVV VVILGILAAM VVPKVLDRPD QARATAARQD IAGLMQALKL
YRLDQGRYPS QAQGLKVLVE KPADAATSNW RAYLERLPND PWGRPYQRGR ERRHRLLAAL
NVDRQRGMAV ISALLVAALV AVIAAGLLAR QARLVRLAEG EGERQAAQWV ARSATAFGLQ
RLRQAWQQDP ATRLDQGWAR GWQLPVTDSA AFDGRLLDEQ GLFNLASLVH EGQLDPLEQA
AFQRLGASVG VAPATLAALE QRLLAAYGEA RLPRPRSLED LAGAPGVEPR ALARLAPFVT
VLPLPGWVNG NTAPAEVIAA RVPGLGLERA RALVAERDRG QGFINSGDLL NRLRLPQLDT
EQVRLGITSE WFRLQGQRRL RLALPPLRLL EPGSVLEGLW LEARGQALPC SVALPTLAAT
LRGAPLELRL HPEDSLLARV ALPPLPAPRL AAAAACALDG LALEGRDALH LAHGPREADG
QVQLAWLARP ALARLQRLLA GVRFRLVPAP FFLPLPPPGQ VSAQCLDGHL VARSGPDHGW
VHPLPALALA EQPDPA
//
