ID A0A182U3Q1_9DIPT Unreviewed; 446 AA.
AC A0A182U3Q1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=BTB domain-containing protein {ECO:0000313|EnsemblMetazoa:AMEC013344-PA};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC013344-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC013344-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC013344-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Putative transcription factor required for axon growth and
CC guidance in the central and peripheral nervous systems. Repels CNS
CC axons away from the midline by promoting the expression of the midline
CC repellent sli and its receptor robo. {ECO:0000256|ARBA:ARBA00037382}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A182U3Q1; -.
DR STRING; 34690.A0A182U3Q1; -.
DR EnsemblMetazoa; AMEC013344-RA; AMEC013344-PA; AMEC013344.
DR VEuPathDB; VectorBase:AMEC013344; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:UniProt.
DR GO; GO:0048813; P:dendrite morphogenesis; IEA:UniProt.
DR GO; GO:0008406; P:gonad development; IEA:UniProt.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IEA:UniProt.
DR GO; GO:0007526; P:larval somatic muscle development; IEA:UniProt.
DR GO; GO:0045476; P:nurse cell apoptotic process; IEA:UniProt.
DR GO; GO:0007464; P:R3/R4 cell fate commitment; IEA:UniProt.
DR GO; GO:0045467; P:R7 cell development; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR CDD; cd18315; BTB_POZ_BAB-like; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR23110; BTB DOMAIN TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR23110:SF114; LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902}.
FT DOMAIN 32..97
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 115..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 47215 MW; A963813155EFEEF4 CRC64;
MDDDQQFCLR WNNHQSTLIS VFDTLLENGT LVDCTLAAEG KLLKAHKVVL SACSPYFATI
LSQQYDKHPI FILKDVKFQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRS
SSSSGTAAAG GGVHQKQSDA PVAKTLQPPV PASKASGLTI ENKRSLKSEL LESDVSGSRE
GSTSPTSRKR KKVRRRSVDT NNLLIDNHDQ HSNSSSHSMH TAGGANVAAA VAAAGAPAAN
VASSLSSASS TAAAGSNTSA NVLSVAAVAA AAVLKKTETV QQAAAETLKL QKQQAAAAAA
AAAAAAQSSD DEERCGPGSV ATGTEHDDGN DLSDNEHDGD GGSSVKSGSR HHHLRDGSRR
GKTSTSSMGE MMIEPKSEYE DVQDENVEDL TMDDEDLMDE LDQAGPSHGG DGLHNGRWNV
SKTKRLLPLR TLLVDNIETH KVSERF
//
