ID A0A182U5T1_9DIPT Unreviewed; 534 AA.
AC A0A182U5T1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 22-FEB-2023, entry version 22.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC014426-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC014426-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC014426-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A182U5T1; -.
DR STRING; 34690.A0A182U5T1; -.
DR EnsemblMetazoa; AMEC014426-RA; AMEC014426-PA; AMEC014426.
DR VEuPathDB; VectorBase:AMEC014426; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF1; RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
FT DOMAIN 363..534
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 58..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..130
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 59855 MW; C033C1A7DEB40B0E CRC64;
MDNDAHGELE AEWLNSAGFP QLTKAFEEGR ELSATELAPV ISGLSSMHAE AVKQRVKALN
RTVRGRTRNR STKKPDIRDV FRDQDSSSTG TRSRSATPDS LDSLPGDDAW NTPPGNGHHH
HHHHHHHPHI PSFVSVFDGN GVVRPTPIRG KQHLRRTPSA PLRGSAELFR GSHIRCDIPI
HNGTIQVKGI ELLNFQRLGT IHIPRIRSGS DPSCTIGPHA GQHISGTRSH TNLYNGSAVA
VRRDNDDSGN SSSEQSPPSS PPRNSLLCSS VENSPLRSSY EPVSFESMIK QTSPSAADQW
EQRPEAAREP CLDIDQISEG EQKRLQPLLW LELASLFDKN HVTLDKRKPF KRKRKEEGNV
FGVSLNALVR RDQQVTGEDT TLVPLVLQTI LAELAVRGAR EEGILRVPGH KQKTEALYNE
IEHNFYCKPE KIDPLIKKAG VHDLSALLKR WLRELPQPLL ANDLVHLFYQ TNVLPPHDQY
KALAVLCQLL PHENRNTLRE LLSFFRRVVE LQDLNKMTQQ NVATIIAPSF FPPR
//
