ID A0A182U6P1_9DIPT Unreviewed; 375 AA.
AC A0A182U6P1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Resistance to inhibitors of cholinesterase protein 3 N-terminal domain-containing protein {ECO:0000259|Pfam:PF15361};
OS Anopheles melas.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=34690 {ECO:0000313|EnsemblMetazoa:AMEC014893-PA, ECO:0000313|Proteomes:UP000075902};
RN [1] {ECO:0000313|Proteomes:UP000075902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CM1001059 {ECO:0000313|Proteomes:UP000075902};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Howell P., Walton C., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles melas CM1001059_A (V2).";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AMEC014893-PA}
RP IDENTIFICATION.
RC STRAIN=CM1001059 {ECO:0000313|EnsemblMetazoa:AMEC014893-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ric-3 family.
CC {ECO:0000256|ARBA:ARBA00008538}.
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DR AlphaFoldDB; A0A182U6P1; -.
DR STRING; 34690.A0A182U6P1; -.
DR EnsemblMetazoa; AMEC014893-RA; AMEC014893-PA; AMEC014893.
DR VEuPathDB; VectorBase:AMEC014893; -.
DR Proteomes; UP000075902; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026160; Ric3.
DR InterPro; IPR032763; RIC3_N.
DR PANTHER; PTHR21723; RESISTANCE TO INHIBITORS OF CHOLINESTERASE PROTEIN 3 RIC3; 1.
DR PANTHER; PTHR21723:SF3; RIC3 ACETYLCHOLINE RECEPTOR CHAPERONE, ISOFORM C; 1.
DR Pfam; PF15361; RIC3; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..169
FT /note="Resistance to inhibitors of cholinesterase protein 3
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15361"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 375 AA; 40280 MW; 4B94CA0701E4DF1C CRC64;
MFKHPGPIPG MRPPMGAGSH QATKSANSMG FIMPLYTIGI VSFFIYTIMK LIFKKTPATP
YTEVKPDPVF RNEVFTTEQY IKRPDDGTTK LVPTSVSNVT NPKFLTLNLA NYSTSVSSGN
NSKSSSLSIA NLSQSGSSLA GGDSADQLME LELLRKKLDE TERAMTKIIA NMGNIPKGQE
TNVNGDEPAT EEKETTSEVN ATEDMVSNGH AIKPADNAAE TTSAVQDTSG GETSSATSTP
EKKPKKRDTS TERGTVKVMA MEVTAQRENG KRLSRPLTPL LPMSGHSDTA NASTEEQETR
SIVLDGRLPH DSKILVSDAE TAVEKMEPEN SEEDDDAPVI LSGKMTLSLI NMDFIEKDAT
GTVAVGGTKT YNSCS
//
